Gelatin, Sodium Alginate Complex Condensation Of Micro Capsules Were Prepared By The Technology Was Studied

In this paper, gelatin and sodium alginate are used as wall materials tomicroencapsulate paeonol through complex coacervation method. The antioxidantcapacity of paeonol microcapsules and the content of paenonl in microcapsules are theevaluating indicators. The antioxidant capacity of paenonl is remarked by its oxidationrate, and its changing in capacity volume is measured via high performance liquidchromatography. The assay methods are all precise and accurate, laying foundation formicroencapsulated technology research.Results of studying wall materials show that the isoelectric point of gelatin is4.5,under which pH the best cohesion proportion of gelatin and sodium alginate is3:1, ofwhich under the condition the maximum yield of complex coacervation of gelatin andsodium alginate is93.5%. SEM reads that the physical membrane structure of thecomplex coacervate gained from gelatin and sodium alginate is dense and smooth withno holes, so that a good membrane structure can be formed, which proves that gelatinand sodium are excellent wall materials for microcapsules.Complex coacervation prepares paeonol oil solution microcapsules, with paeonoloil solution as capsule core, and using single factor experiment to establish the optimumtechnological conditions that the proportion of capsule core and wall materials is3:2,the curing agent concentration is3%, the anti-adhesive content is1%, and the emulsifieris RH40. The experimental results show that the antioxidant capacity of preparedmicrocapsules is good, and the microcapsule is in spheroidal shape, besides, thedispersion is good, and the surface of the capsule shell is smooth, with an averageparticle size of7.30μm.Complex coacervation prepares paenonl crystal microcapsules, with paenonlcrystal as capsule core, and through single factor experiments and central composite design-response surface methodology to establish the optimum process conditions areas follows: the drug loading is28.46%, the CaCl2concentration is8.10%, the gelatinsolution concentration is3.87%, and sodium alginate concentration is1.29%.Laboratory results show: the antioxidant capacity of microcapsules is good, and themicromorphology inspections indicated that the outside surface of microcapsules is notsmooth, which is irregularly shaped outside, and particles’ diameter is in narrow rangewith an average particle size of13.16μm.The experiments proved that the complex coacervation of gelatin and sodiumalginate can wrap solid drugs, ester-like drugs and fat-soluble drugs so as to formmicrocapsules. Accelerated test also proved that the wall materials formed by gelatinand sodium alginate through complex coacervation can protect capsule core from beingoxidized. So the microcapsules prepared by gelatin and sodium alginate complexcoacervation are with favorable antioxidant capacity.