The Effects To TNF-α And IL-6of Heart-spleen Deficiency Insomnia Patients By Acupunctur Combining With Massage

Objective：Observation the Curative effects of two treatments ofacupuncture on five-Zang back-Shu acuacupoints (includingtwo-sided xinshu, liver, lungs, spleen, kidneys Shu) combining withmassage the Bladder Channel of Foot-Taiyang effects forHeart-Spleen deficiency insomnia and the levels changes of twocytokine of tumor necrosis factor alpha (TNF-α) and Interleukin6（IL-6）in the serum after treatment. Exploration of mechanism ofacupuncture combined with massage for treatment of insomnia.Looking for a better method of treatment for Heart-Spleendeficiency insomnia, to help the increasing number of patients whoare disturbed by it.Methods: Using randomized testing method,64patients withHeart-Spleen deficiency insomnia are randomly assigned to twogroups of acupuncture with massage group and drug group, with32patients of each group. Acupuncture with massage group first takestwo-sided xinshu, liver, lungs, spleen, kidneys shu acuacupoints,with entwisting maneuver tonifying method for xinshu and spleen shuand flat filling-in purging technique for other acuacupoints afteracupuncturing; and then chooses massage method, rolling method,plucked method, brush method and other methods on the BladderChannel of back and waist. Drug group oral administration of Estazolam1～2mg before sleep. Detect the insomnia patients’ TNF-αand IL-6level in the serum by Enzyme-linked immunoassay (ELISA),and observe the changes of sleep before and after treatment.Results: Compared with before treatment, the sleep quality of thetwo groups of insomnia patients has improved significantly. For theacupuncture with massage group,18cases are all recovered,6casesare excellently recovered,4cases are effectively recovered,1cases is lost and rejected1case,the total effective rate is93.3%;for the drug group,14cases are all recovered,6cases areexcellently recovered,5cases are effectively recovered,2casesare lost, the total effective rate is83.3%. The levels of serumTNF-α of the two groups are both significantly higher than beforetreatment (P<0.05), the levels of serum IL-6of the Two groups areboth significantly reduced than before treatment (P<0.05), and thechanges of the two serum cytokines levels of acupuncture withmassage group are more significantly.Conclusions: Acupuncturing five-Zang back-Shu acuacupoints withmassaging Bladder Channel can adjust serum levels of TNF-α andIL-6and improve sleep quality of Heart-Spleen deficiency insomniapatients; and the effect is better than oralling sedativehypnotics.