Study Of Clinical Significance Of SYK And EGFR And HER2Protein Expression In Gastric Carcinoma

Objective:To investigate the expressions of spleen tyrosine kinase protein (SYK), epidermal growth factor receptor1(EGFR1) protein and the human epidermal growth factor receptor2(HER2) protein in gastric carcinoma, and their relationship with the occurrence and development of gastric carcinoma.Methods:The expressions of SYK and EGFR and HER2protein were detected by immunohistochemical method in55samples of gastric carcinoma from55cases and20samples of the cancer adjacent tissue of20cases. The expressions of SYK and EGFR and HER2proteins were analyzed with following factors:the pathological stages, TNM stages, lymph node metastasis, serous membrane infiltration and distant metastasis.Results:Immunohistochemical assays showed that the positive rate of the SYK, EGFR and HER2were21.8%(12/55),41.8%(23/55) and29.1%(16/55) respectively in all55gastric carcinoma patients. Whereas in pericancerous tissues of20cases the positive rate were85.0%(17/20) for SYK,0for EGFR and0for HER2. These data showed that the high expression of EGFR and HER2is remarkably related to the histologic types, tumor TNM staging, lymph node metastasis, serous infiltration and distant metastasis of the tumor (P<0.05), but not to the age and gender of invovled patients. On the contrary the protein level of SYK is negatively correlated to the above factors except age and gender. In extremely situations for example in poorly differentiated adenocarcinoma SYK protein could not be detected. The expression of SYK and HER2are negative correlated (r=-0.340), the same with SYK and EGFR (r=0.345). On the contrary, the correlation between HER2and EGFR is positive (r=0.350).Conclusion:We concluded that both the deficiency of SYK and the high expression of EGFR and HER2have a close relevance to the malignant biological behaviors including proliferation, penetration and metastasis of gastric carcinoma. Detection of SYK and EGFR and HER2protein expression can be used to assess the malignant biological behavior and the prognosis of gastric carcinoma, providing a target for therapy of gastric carcinoma.