| Objective Observation of replenishing qi to invigorate the spleen combined with exenatide in type2diabetes with deficiency of the spleen syndrome of phlegm and blood stasis in patients with blood glucose control and islet function of influence;and exenatide group, evaluation of traditional Chinese medicine and integrated Chinese and Western Medicine on the treatment of type2diabetes role.Methods1, a clinical prospective randomized study. Will be consistent with the syndrome of traditional Chinese medicine according to the visiting tutor outpatients randomly divided into the treatment group (30cases); many hospitals of pure exenatide were randomized into control group (30cases). Control group is given exenatide injection5ug,bid;4weeks later renamed10ug bid. The total treatment is12weeks. The treatment group in the control group treatment scheme based on self-made Yiqi Jianpi Recipe to tutor (provisional).2, Observe the two groups before and after treatment the symptoms, signs, complete syndrome integral quantization table.3,Two groups were observed before and after treatment of fasting blood glucoseand standard2hour postprandial blood glucose, glycosylated, hemoglobin, body weight, body mass index, triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein the cholesterol, C peptide level, the function of islet B cell index, insulin resistance index, liver function, renal function, blood, urine and other safety index, related statistical analysis, compare the difference between the two groups.Results1, TCM syndrome integral:comparison of curative effect in treatment group was obviously better than that of the control group.2, TCM efficacy total effectiveness respectively:the clinical cure rate and efficiency are better than the control group.3, After the treatment, glycosylated hemoglobin, standard2h postprandial plasma glucose, fasting insulin, insulin resistance index decreased (P<0.05) in two groups;fasting C peptide, pancreatic islet beta cell function index increased (P<0.05), the treatment group than in control group (P<0.05). The control group of fasting glucose compared before and after treatment (P>0.05), the difference was not statistically significant;4, lipid profile comparison:the treatment group after treatment, serum total cholesterol, triglyceride, low density lipoprotein than before treatment were decreased significantly (P<005, P<0.01); HDL elevation is not obvious (P>0.05). The control group before and after treatment with lipid profile changes; in treatment group than in control group (P<0.05), between group comparison of LDL (P>0.05), no statistically significant differences.5, body weight, body mass index:comparison of two groups after the treatment, body weight, body mass index compared with before treatment have reduced (P<0.05), group comparison in treatment group than in control group (P<0.05).Conclusion Replenishing qi to invigorate the spleen method combined with Ai Sai that peptides can significantly improve type2diabetes patients with spleen deficiency syndrome of phlegm and blood stasis of TCM symptoms and signs; significantly lower blood glucose, blood lipid, improved the function of islet, increased insulin secretion, to delay the course of diabetes play an important role in the development. Replenishing qi to invigorate the spleen combined with exenatide in clinical application without obvious adverse reaction. Combination of traditional Chinese and Western medicine and simple western medicine control, faster weight loss, reduce the pure western medicine compliance of patients with adverse reaction, improve clinical curative effect, be better reflected. Combination of Chinese medicine and Western medicine for the treatment of type2diabetes is one of the effective methods of. Worthy of clinical application. |
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