Clinical Study And TCM Syndrome Diffferentiation Hormone Reasearch On The Use Of The Bushenqudu Decoction In CRF With Qi Deficiency Of Spleen And Kidney

Objective:Through the use of the syndrome elements differentiation system to observe the Chronic Renal Failure patients in qi deficiency of spleen and kidney with Bushenqudu Decoction and the clinical study about the expression of serum creatinine, blood urea nitrogen, serum uric acid, serum albumin, hemoglobin, transforming growth factor-β1,bone morphogenetic protein-7and other biochemical parameters before and after treatment.Methods:68cases which met inclusion criteria choose from December2010to February2012in Fuzhou General Hospital of Nanjing Military Region and The Second People’s Hospital of FuJian Province. This study used a non-randomized controlled clinical observation in the same period of law, these cases were divided into treatment group34cases and34cases of the control group. Treatment group treated with Bushenqudu Decoction, while control group treated with Uremic Clearance Granule. Collect information input syndrome identificatied system to observed the changes of traditional chinese medicine(TCM) syndrome diffferentiation hormone before and after three monthly treatment and statistical analysis biochemical parameters.Result:From the changes of68cases syndrome elements, the focuses of the Chronic Renal Failure(CRF) patients with qi deficiency of spleen and kidney closely related to kidney, spleen, follow by heart, liver, lung and so on. The mainly natures of diseases are qi deficiency, yang deficiency, dampness, blood deficiency, yin deficiency, water retention, damage of essence, phlegm, heat, qi sinking and so on. Before treatment there are no significant differences between each syndrome elements(P>0.05). Treatment group has significant differences in kidney, spleen, qi deficiency, yang deficiency, blood deficiency,(P<0.05). Control group has significant differences in kidney, spleen, qi deficiency, yang deficiency (P<0.05).The between-groups comparison was not significant except blood deficiency(P<0.05). Before treatment in the primary disease, clinical stage, age, sex, the syndrome element calculus and related chemical examination level of each group among the Uremic Clearance Granule and Bushenqudu Decoction groups are not significantly increased (P>0.05). The expression of TGF-β1has a positive correlation with BMP-7.And the latter decreased more significantly than the former (P<0.01or P<0.05). There is more significantly difference in the serum albumin, urea nitrogen,blood deficiency between the two groups (P<0.05)Conclusions:The mainly locations of the Chronic Renal Failure patients with qi deficiency of spleen and kidney are kidney, spleen, the mainly natures of diseases are qi deficiency, yang deficiency, dampness, blood deficiency, which accorded with complication pathogenesis. The syndrome identificatied system can comprehensively display the the syndrome elements. The Bushenqudu Decoction can improve symptoms,such as qi deficiency, yang deficiency, blood deficiency. Treatment group treated with Bushenqudu Decoction has the feasibility and effectiveness in improving the renal function, serum albumin and so on. Bushenqudu Decoction could reduce the expression of TGF-β1, and promote BMP-7, which result to inhibition to the progress of Renal Interstitial Fibrosis (RTF) in the CRF,Which may be one of the target for Bushenqudu Decoction.