Endocrine Therapy In The High Risk Population Zhong Dao Tube Proliferative Lesion Of Applications

Objective: To study the expression of the71cases of intraductal lesions of estrogenand progesterone hormone receptor.And analysis of this group of patients,age atmenarche,first live births,age,family history,history of breast biopsy,especially atypicalhyperplasia,a history of relevant factors presented in high-risk groups prophylacticaromatase inhibitors preventive treatmnt,especially for postmenopausal women.Fornon-high-risk,but estrogen and progesterone receptor-positive patients treated withlow-dose,short-term anti-estrogen therapy (aromatase inhibitors).Methods: From July2011to September received treatment in hospital breast Branch to considerspace-occupying lesions within the ductal given section of the ductresection,postoperative specimens for immunohistochemical ER and PRanalysis.Analysis of ER,the relationship between the PR immunohistochemistry usingtheχ~2test and rank sum test.Results:71cases of postoperative cases confirmedintraductal proliferative lesions of patients,including expansion of adenosis with catheterin19cases (26.76%),ductal hyperplasia,30cases (42.25%),intraductal papilloma in17cases (23.94%),intraductal dysplasia in3cases (4.22%),two cases of ductal carcinoma insitu (2.82%).Each group of diseases in the inter-ethnic distribution was no significantdifference (P＞0.05).Postmenopausal patients before and postmenopausal patients withpositive expression rate of the difference was not statistically different (P＜0.05).Although the positive rate between the results of this experiment made nosignificant difference considering the number of samples is not enough,but this group ofdiseases intraductal papilloma,ductal epithelial hyperplasia washigher,ER,respectively,93.3%,94.1%; the PR,respectively,89.5%,76.1%; prompt higherER and PR expression in the proliferative lesions within the catheter.The expression ofER compared with PR expression,the difference was not statistically significant.Conclusion: intraductal proliferative lesions of ER and PR expression arehigh,the ER expression is higher than that of PR.Foreign phase III trial,suggesting thatER-positive patients were given preventive treatment to the aromatase inhibitor.Whetherto give anti-estrogen therapy to prevent breast cancer in these high expression in benignlesions.