The Clinical Observation About Zhong Man Fen Xiao Pill Treating Cirrhosis Of The Liver Decompensation Period And Ascites Patients Whose Tcm Syndrome Are Damp And Hot Accumulate Knot Type

Objective:To objective the recent clinical effects with Zhong Man Fen Xiao pill treating of cirrhosis of the liver decompensation period and ascites patients, whose Chinese Medicine Syndrome Type is damp and hot accumulate knot type。The aim is Providing references for clinical care about Cirrhosis of the liver decompensation period and ascitesMethods:1、Sixty-one patients diagnosed with cirrhosis of the liver decompensation period and ascites divided into two groups randomly, the treatment group is thirty-one cases, twenty cases of male and eleven cases of female, the control group is thirty cases, twenty-one cases of male and nine cases of female. The Control group is given treatment on protect liver (glutathione, Glycyrrhizin, Polyene Phosphatidyl Choline), diuresis (spironolactone, Speed diapers), appropriate albumin, Symptomatic treatment, such as Fight infection(cefotaxime sodium for injection), Suppression of acid (Pantoprazole), Correct electrolyte disorders abatement of fever and so on. The treatment group is taken the decoction of Zhong man fen xiao pill besides taking the medicines as same as the control group. The period of treatment is four weeks.2、Observe two groups of patients before and after treatment of the major Chinese Medicine Syndrome Type’s and abdominal circumference changes, and blood analysis (White blood cells、the proportion of the neutrophils), and main biochemical indicators of change such as liver function (alanine amino-transferase、aspartate aminotransferase、Total bilirubin、albumin), Kidney function(Blood Urea Nitrogen、Creatinine),electrolyte(Kalium、Natrium、Chlorine), Ascites white blood cells, Ascites pleomorphic nuclear white blood cells, and change of ascites, and Compared the two groups curative effect.Consequence:1、Comprehensive curative effect compared:After treatment, the total effective rate of the treatment group is70.97%, is better than the control group whose the total effective rate is43.33%, p<0.05, it is a statistical significance.2、Ascites subsidise compared:the total effective rate about the treatment group is77.42%, which the remarkable curative effect is nine, effective is fifteen, no effect is seven,and the total effective rate about the control group is50.00%, which the remarkable curative effect is five, effective is ten, no effect is fifteen, the treatment group is better than the control group, p <0.05, it is a statistical significance.3、The major Chinese Medicine Syndrome Type compared:After treatment, the total effective rate of the treatment group is83.87%, is better than the control group whose the total effective rate is46.67%, p<0.05, there are significant differences. After treatment, the two groups compared in the group:the major Chinese Medicine Syndrome Type of the treatment group improved obviously, p<0.05; the control group improved ob-viously on Big and full of belly and abdominal distension and yellow about body and eye and short and yellow about pee,which is p<0.05. The abdominal circumference of the two group are better than before. Comparison between groups after treatment, the treatment group is better obviously than the control group on symptoms of big and full of belly, abdominal distension, thirsty but less drink, bitter taste,which is p<0.01; The symptoms of yellow about body and eye and short and yellow about pee of the treatment group is better than the control group too, which is p<0.05;It is not a statistical significance about Shit or weight or abdominal circumferences4、Laboratory testing index compared:After treatment, the two groups compared in the group:The alanine aminotransferase and aspartate aminotransferase and Total bilirubin and Ascites white blood cells and Ascites pleomorphic nuclear white blood cells of the two group are declined obviously than before。And the albumin and Natrium has rised than before, which is p<0.05. The Creatinine and Kalium and Chlorine of the two group have not changed obviously; And the White blood cells and the proportion of the neutrophils and Blood Urea Nitrogen of the treatment group are better than before, but not the control group.Comparison between groups after treatment:The Total bilirubin and Ascites white blood cells and Ascites pleomorphic nuclear white blood cells of the treatment group are better obviously than the control group, which is p<0.05. The two group have no statistical difference on improved White blood cells or the proportion of the neutrophils or alanine aminotrans-ferase or aspartate aminotransferase or albumin or Blood Urea Nitrogen or Creatinine or Kalium or Natrium or Chlorine。Conclusion:It indicated the effectiveness of Zhong man fen xiao pill treating decompensated cirrhosis of the liver stage and ascites patients whose syndromes was damp and hot accumulate knot type, which can improve the main Chinese Medicine Syndrome Type, promote ascites subsidise, and control ascites infection In the treatment course, patients have not significant adverse reactions,so Zhong man fen xiao pill is worth to clinical use and further research.