Quantitative Eeg Analysis Of Patients With Generalized Tonic-Clonic Seizures Treated With Sustaeved-Release Form Of Sodium Valproate

Objective:To investigate the effects of sustained-release form of Sodium valproate (Depakene) on newly diagnosed generalized tonic-clonic seizures patient with quantitative electroencephalogram (QEEG) analysis and to explore the correlation of electroencephalogram changes and therapeutic efficacy.Methods:Eleven newly diagnosed, untreated GTCS patients were recruited and treated with SR-VPA. During the six-month follow up, all patients underwent EEG-recording and MMSE examination at the three time points:before initiating SR-VPA therapy,1month and3months after treatment respectively. EEG background frequency was analyzed by using the fast foureier transform(FFT). Both the seizure frequency and side effects were recorded. Absolute energy (AE), alpha band mean frequency (AMF) and the percentage of six frequency bands (δ=0-3.9Hz,θ=4.0-7.9Hz, alpha1=8.0-9.9Hz, α2=10-13Hz, β1=14.0-18.0Hz, β2=19-30Hz) were computed for16derivations. Parameters were inputted to the Excel database, and the SPSS19.0statistical description and statistical analysis.Results:1) Absolute energy alpha, beta, theta and delta were significantly decreased in the one month treatment group (SR-VPA) compared with those of before initiating SR-VPA therapy (P<0.05). And there is statistically significant in delta band (P<0.05), theta band(P<0.03) and partial alpha1band (p<0.05);2) Mean frequency within alpha band and its absolute energy showed no difference between the1month treatment group and before treatment group. In addition, there could be noticed an increase of the percentage of beta band for partial derivations.3) There was significant correlation between VPA-related AE decrease and the initial AE abnormality.4) During the first month of Depakene treatment, all patients hadn’t seizure attack. But seizures were occurred in two cases in the3-month following up. Mild side effects were observed in3patients after taking Depakene;Conclusions:1)Short-term Depakene treatment only selectively decreases the activi ty of the abnormal EEG synchronization, but does not cause significant change of alpha mean frequency and percentage of six bands AE. 2) Changes in alpha, beta, theta and δ-band AE closely correlate with baseline abnormal.3) Changes of δ,θ,α2-band AE may reflect efficacy of Depakene.