Experimental And Clinical Research Of Jiangni Humo Soup To Prevent Relapse And Restrain The Acid In The Reflux Esophagitis

Objective:To study COX-2and PCNA in and claudin-1expression in esophageal mucosa of reflux esophagitis rat model and Jiangni retaining membrane soup of COX-2, PCNA and claudin-1expression; observed Jiangni care The clinical efficacy and recurrence rate of membrane soup plus omeprazole therapy for reflux esophagitis.Methods:Incomplete pyloric ligation cardia muscle incision,"Preparation of reflux esophagitis rat model,80rats were divided into normal group, model group and sham group, the positive control group (omeprazole), traditional Chinese medicinesmall dose group, middle dose group, high dose group, integrative medicine group (Jiangni, retaining membrane soup+omeprazole). To give appropriate treatment, the Organization for Esophageal HE staining histopathological changes observed under light microscope to detect COX-2, PCNA and claudin-1expression using immunohistochemical methods.60cases in line with the diagnosis of reflux esophagitis patients were randomly divided into treatment and control groups. The treatment group to Jiangni retaining membrane soup plus omeprazole treatment, control group I omeprazole treatment, six months after the end of8weeks treatment follow-up. Improvement of symptoms and recurrence after treatment were observed.Results:The laboratory findings showed:Jiangni retaining membrane soup can significantly change the pathological changes of the esophageal mucosa of reflux esophagitis rat model, soup, small-dose group of Jiangni retaining membrane, the middle dose group, the high-dose group, the positive control group Integrative Medicine group of esophageal pathological changes significantly reduced; Jiangni retaining membrane soup significantly inhibited the expression of PCNA and of claudin-1; The COX-2was no obvious expression..The clinical observation:symptoms improved RDQ points change before and after treatment, the treatment group compared with the control group,8weeks of treatment efficacy, but six months of the treatment group relapse rate is much lower than the control group, statistical differences between the groups (P<0.05); Chinese medicine symptom efficacy outcomes of treatment for eight weeks and the end of June follow-up, treatment group was significantly higher (P<0.05);observed after8weeks of treatment; the six month follow-up after the end of treatment, the treatment group relapse rate was significantly lower than the control group (P<0.05).Conclusion:Conclusion:Jiangni cuticle soup plus omeprazole may improve the clinical symptoms of reflux esophagitis in patients with lower relapse rates, and improve patients’ quality of life; Jiangni retaining membrane soup has to repair the esophagus damaged mucosa, inhibition of cell over-proliferation, control esophageal epithelial proliferation and cell gap widened, to prevent the further development of the disease, the prevention of Barrett’s esophagus, esophageal adenocarcinoma has a positive meaning.