Evaluate The Clinical Performance And Quality Of Life Of The Mosaic Bioprosthesis In Valve Replacement At Early Period Postoperativly

Objective To evaluate the hemodynamic performance including peak gradients, mean gradients, the effective orifice areas and peak velocity of the Mosaic bioprosthesis in valve replacement, and investigate the improvement of left cardiac function and quality of life after valve replacement.Methods59patients underwent valve replacement with Mosaic bioprothesis in hospital,33patients underwent mitral valve replacement,26patients underwent aortic valve replacement. Doppler echocardiograms were recorded before operation1week、3month and1year after valve replacement. Record hemodynamic performance(peak gradients, mean gradients, the effective orifice areas and peak velocity) and left cardiac function (left atrial diameter, left ventricular diastolic diameter, left ventricular systolic diameter, left ventricular ejection fraction, pulmonary artery pressure). Two questionnaires about the quality of life:Nottingham Healthy Profile(Part I)(NHP), Duke Activity Status Index (DASI) were used preoperatively and postoperatively1year.Results (1)33patients with MVR, the peak gradients, mean gradients, the effective orifice areas and peak velocity were respectively (18.4±4.4)mmHg、(6.6±1.3)mmHg,(1.9±0.4)cm2and (2.1±0.3)m/s. Left atrial diameter, left ventricular diastolic diameter, left ventricular systolic diameter were significant different between preoperation and postoperation at1week,3month and1year (P<0.05); there was no significant difference in left ventricular ejection fraction preoperatively and postoperatively(P>0.05). Left atrial diameter, left ventricular diastolic diameter, left ventricular systolic diameter were no significant difference at different time preoperatively (P>0.05). Pulmonary artery pressure was significant different between1week and1year preoperatively (P<0.05); was significant different between3month and1year preoperatively (P<0.05); was no significant different between1week and3month (P>0.05).26patients with AVR, the peak gradients, mean gradients, the effective orifice areas and peak velocity were respectively (34.6±11.7)mmHg、(14.3±5.8)mmHg,(1.5±0.2)cm2and (2.8±0.6)m/s. Left atrial diameter, left ventricular diastolic diameter were significant different between preoperation and postoperation at1week,3month and1year (P<0.05);there were no significant difference at different time preoperatively(P>0.05).Left ventricular systolic diameter、 left ventricular ejection fraction、pulmonary artery pressure were significant different between preoperation and postoperation at1year (P<0.05); there were no significant difference between preoperation and postoperation at1week,3month (P>0.05). Left ventricular systolic diameter was no significant difference at different time preoperatively(P>0.05). Left ventricular ejection fraction and pulmonary artery pressure were significant different between1week and1year preoperatively(P<0.05); were significant different between3month and1year preoperatively (P<0.05); were no significant different between1week and3month (P>0.05).(2) Patients with valve replacement, Nottingham Healthy Profile(Part I)(NHP),86.4±18.44vs.121.5±27.6; Duke Activity Status Index (DASI),6.15±1.42vs.4.21±1.24were significant different between preoperatively and postoperatively1year.Conclusions After1years of follow-up, Mosaic bioprosthesis demonstrates excellent hemodynamic performance, patients left cardiac function restored and quality of life improved.