The Expression And Significance Of CXCR4in Recurrent Glioma

Objective To investigate the protein expression of chemokine receptor CXCR4in human primary gliomas and recurrent gliomas,to explore the value of CXCR4as grade rating factors and therapy targets for human gliomas.Materials and methods We collected cases in human glioma and divided them into primary and recurrent groups,both of them had31cases.We studied the expression of CXCR4by immunohistochemical (S-P), SPSS13.0was used to analyze the relations between their expression and clinical pathologic factors (such as pathological grade, tumor size, the expression of vimentin and the expression of Ki-67).Results There was no CXCR4expression in10cases of normal brain tissue(0.0%). The positive CXCR4was61.2%(19/31) in human primary glioma tissues, and the positive CXCR4was87.1%(27/31) in human recurrent glioma tissues. The positive expression rate of CXCR4in the recurrent group increased significantly. The expression of CXCR4had no correlation with tumor size and the expression of vimentin,but the expression was positively correlated to pathological grade and the expression of Ki67.Conclusion The chemokine receptor CXCR4was not expressed in normal brain tissues, but the expression of CXCR4was higher in human primary and recurrent glioma tissues than in normal brain tissues, that suggested CXCR4may be related to the invasiveness of glioma; the expression of CXCR4was increased with the rise of pathological grade, and had a positive correlation with the expression of Ki-67,suggested that CXCR4may be associated with malignant gliomas, and possibly as a classification factor of the gliomas grade;the expression of CXCR4in human glioma tissues was higher, especially in recurrence groups, it could reduce the invasion and proliferation of glioma cell by CXCR4as a therapeutic target,it maybe a potentially powerful means of treatment in gliomas when the traditional means was not in effect.