Therapeutic Efifcacy Of Transurethral Holmium Laser Combined With Single And Multiple Intravesical Instillation Of Pirarubicin In The Treatment Of Cystitis Glandulairs

Objective: To compare the clinical efficacy of transurethral holmium laser combinedwith single and multiple intravesical instillation of pirarubicin in the treatment ofcystitis glandularis.Methods: The clinical data of44cases were reviewed in our department in the timefrom October2009to December2010.The patients were divided into two groups. Onegroup of25cases was treated by transurethral holmium laser combined with bladderinstillation of pirarubicin one time after surgery, followed by continuous instillationonce a week for8times. The other group of19cases was treated by transurethralholmium laser combined with bladder instillation of pirarubicin one time after surgery.Effects on different group of patients were compared. T test was used in disease-freeinterval between the two groups, χ2test was used in the recurrence rate and incidenceof adverse to compare, P0.05was considered statistically significant.Results: The two groups were followed up by6to15months, Multiple instillationGroup:13cases were cured,10cases were improved,2cases were ineffective,theeffective rate was92.0%,the recurrence rate was8.0%;Single instillation group:7caseswere cured,5cases were improved,7cases were ineffective, the effective rate was63.15%, the recurrence rate was36.84%. The two groups have significant difference(2=3.889,P<0.05).Low incidence of adverse reaction of two group of patients after surgery,no complications occurred,the short term given the perfusion had low adversereactions,the patient could be tolerated and not stopped due to adverse drug perfusion,itdoes not affect the course of conduct.Conclusion：1) Multiple intravesical instillation of pirarubicin after the surgery of cystitis glandularisby transurethral holmium laser can increase the efficiency, is an effective treatmentway.2) Intravesical instillation of pirarubicin has low toxicity, is a safe and effectiveintravesical instillation of drugs.3)Single instillation of pirarubicin after treatment of cystitis glandularis by transurethralholmium can not to provide effective treatment.4)Recessive lesion of cystitis glandularis surgery can not be the complete removal ofdiseased tissue,especially in the early hidden lesion,postoperative multiple intravesicalinstillation can significantly compensate for this shortcoming,and thus effectiveprevention of recurrence.