Various Tissue Types Of Glandular Cystitis And Bladder Cancer In Rasp <sub> 21 </ Sub> Protein Expression And Significance

PURPOSE: Investigate expression of RasP₂₁ in Cystitis glandularis(CG) and bladder primary tumor to research whether CG is one of premalignant lesion and which subtype has much more malignant potential. METHODS: Immunohistochemistry were used to demonstrate the expression of RasP₂₁ in 60 cases of CG and Bladder Transitional cell Carcinoma (BTCC) and 11 cases of bladder adenocarcinoma and 10 cases normal bladder tissue. RESULTS: Normal transitional epithelioid cells were demonstrated negative for RasP₂₁. Among the CG there were 17 cases tested positive, the rate of expression was 28.33%(17/60),especially that of the intestinal subtype was 6 in 14( 42.86%). Among the BTCC there were 22 cases tested positive for RasP₂₁, about 36.67%(22/60),and 6 cases were tested positive in bladder adenocarcinoma, about 54.54%. RasP₂₁-positive expression among four groups was demonstrated statistic meaning(p<0.05),there is to said ,the strength of expression increased in turns. The strength of expression decreased after Gâ… or Tis-T1 stage in BTCC(p<0.05). There were no differential expression among the intestinal subtype CG,BTCC and bladder adenocarcinoma(p>0.05). CONCLUTION: Cystitis glandularis may be a premalignant lesion in bladder, especially the intestinal subtype CG. The RasP₂₁-positive CG should have a regular followed-up for early detection of bladder cancer.