Related Factors Of The Different Degree Of Anemia In Preterm Infants

Objective To investigate the perinatal risk factors and possiblepreventive measures for anemia in preterm infants.Method136preterm infants admitted to the department ofneonatology in children’s hospital of Chongqing medical university fromJanuary2010to December2010were recruitted.According the hemoglobinlevel, the infants were classified into two groups: mild-to-moderate anemia(n=87) and severe anemia (n=49). All medical data were collected andanalyzed by the univariate analysis and Logistic regression methods.Result Through univariate analysis,we found out the gestational age(31.71±2.19weeks vs32.76±2.13weeks),birth weight (1657.45±433.36gvs1885.32±485.33g) and birth hemoglobin value (148.35±19.26g/L vs161.22±20.8g/L) of the severe anemia group were significantly lower thanthose of the mild-to-moderate anemia group(P＜0.05).The iatrogenic bloodloss (12.28±4ml/Kg vs10.05±3.34ml/Kg) and days of hospital stay(30.8±16.62d vs21.43±11.81d) of the severe anemia group were significantly higher than those of the control group(P＜0.05).In multiplefactor logistic regression analysis, compared with the preterm infantswhose iatrogenic blood loss was＜7ml/Kg,the OR values of the preterminfants whose iatrogenic blood loss was7～13ml/Kg and more than3ml/Kg were1.575（95%CI:0.572～4.707）and5.146（95%CI:1.35519～19.542）seperately. The analysis results also revealed that the days ofhospital stay was the risk factor of severe anemia, its OR was1.029. Whilebirth hemoglobin was the protective factor(OR=0.962) of severe anemia inpreterm infants.Conclusion The severity of anemia in preterm infants is associatedwith gestational age, birth weight, birth hemoglobin level right after birthand days of hospital stay as well as iatrogenic blood loss. The iatrogenicblood loss and days of hospital stay are independent risk factor in severeanemia of prematurity. Appropriate increasing the birth hemoglobin levelafter birth, minimizing the iatrogenic blood loss and shortening the hospitalstay may be effective in preventing the occurrence of severe anemia inpreterm infants.