Study On The Liver And Spleen Volume Changes In Chronic Hepatic Fibrosis And Cirrhosis With64-slice CT

ObjectiveThe paper was designed to study the change trend of the liver lobe volume, the total liver volume and spleen volume in the different pathological stages of chronic liver fibrosis and cirrhosis by the64-slice spiral CT. And compare the above-mentioned indexes with pathological stage and liver function Child-Pugh classification of chronic liver fibrosis and cirrhosis, analyze the pathological basis and liver function parameters. To explore the rule and its causes of change trend of volume with the progression of liver fibrosis cirrhosis.Materials and Methods1. To collect41patients of hepatic fibrosis and cirrhosis caused by the hepatitis which including29of males and12of females. All of patients were recently confirmed by pathology, laboratory and imaging studies (including7cases of S1,10cases of S2,4cases of S3,5cases of S4,15cases of cirrhosis). Which include16cases of A,11cases of B,14cases of C in hepatic function. And collect15healthy adults which have no history of liver disease. The standard of bringing:they have no mass lesions confirmed by pathology, laboratory and imaging studies.2. All of the participants(41patients and15healthy) undertake abdominal64-slice CT enhanced scans, then measure their hepatic and splenic volume respectively and calculate the percentage of every lobe of the liver, liver and spleen volume ratio. Eventually compare the above indicators with hepatic fibrosis period and hepatic function. Analyze the dates by the statistical package of SPSS17.0. It is thought to be significative when P<0.05.ResultsFrom normal to cirrhosis, right lobe, left interior lobe, their percentages and the total liver volume firstly increase then decrease; By the ANOVA and SNK test, in the above indexes, the volume of right lobe. left interior lobe and the total liver have significant differences between advanced cirrhosis and other groups (P<0.05); the volume of right lobe have significant differences between normal, S2and S4groups(P<0.05); the volume of left interior lobe have significant differences between S2and S4groups(P<0.05); the total liver volume have significant differences between normal and S2groups(P<0.05).Hepatic left lateral lobe, caudate lobe volume and their percentages increases gradually; By the ANOVA and SNK test, in the above indexes, hepatic left lateral lobe and caudate lobe volume have significant differences between advanced cirrhosis and other groups(P<0.05); the volume of hepatic left lateral lobe have significant differences between S4, S1and S3groups(P<0.05).The size of spleen increase gradually. By the ANOVA and SNK test, in the above indexes, the spleen volume have significant differences between advanced cirrhosis and other groups(P<0.05);the vertical diameter of spleen have significant differences between advanced cirrhosis and normal,S1, S2, S3groups; Anteroposterior diameter have significant differences between normal and S2, S3, S4and advanced cirrhosis groups. Transverse diameter have significant differences between advanced cirrhosis and S4, S1,S2and normal groups.From Child-Pugh A to C, right lobe, left interior lobe and the total liver volume decreases, hepatic left lateral lobe and caudate lobe volume increases gradually.ConclusionThe volume changes of the liver and spleen have a certain regularity, and have obvious relevance with liver fibrosis and liver function Child-Pugh classification. From normal to cirrhosis, right lobe, left interior lobe, their percentages and the total liver volume firstly increase then decrease; Hepatic left lateral lobe, caudate lobe volume and their percentages increases gradually; The size of spleen increase gradually. From Child-Pugh A to C, right lobe, left interior lobe and the total liver volume decreases, hepatic left lateral lobe and caudate lobe volume increases gradually.