Therapeutic Observa Of Palmoplantar Pustulosis Treated With Acitretin And Tripterygium Glycosides

Background: palmoplantar pustulosis is a disease that have still not fullyunderstand its pathogeny, occurs in the palms and soles, it is a chronic,relapsing, inflammatory disease. Most people think that the pathogenesis ofimmunology plays an important part in palmoplantar pustulosis, but also somepeople think that the disease is localized pustular psoriasis.The typical clinicalperformance is small, sterile, deeply pustules occurred periodic based inerythema, with keratinize and take off bits. Treatment methods are various，forexample Tretinoin、immunosuppressive agents、biological regulator、antibiotic and physical therapy，but curative effect is still not quite satisfiedwith.The report about palmoplantar pustulosis treated with Acitretin andTripterygium Glycosides is rarely.Objective：To observe the efficacy of palmoplantar pustulosis treated withAcitretin and Tripterygium Glycosides.Methods:102out-patients were randomly divided into3groups whichwere treated by Acitretin and Tripterygium Glycosides, Acitretin,Tripterygium。At the same time all use compound clobetasol propionate ointment externally intwo months，and then to compare treatment datas。Results: The effective rate of Acitretin and Tripterygium Glycosides groupis higher than the other two groups in2weeks later(The effective rate ofAcitretin and Tripterygium Glycosides group is92.31%, Acitretin group is64.52%and Tripterygium Glycosides group is62.5%)。 Acitretin and TripterygiumGlycosides group to Acitretin group is X~2=9.092，P=0.028<0.05, there arestatistically significant differences between the two groups; Acitretin and Tripterygium Glycosides group to Tripterygium Glycosides group is X~2=11.084，P=0.011<0.05, there are statistically significant differences between the twogroups; Acitretin group to Tripterygium Glycosides group is X~2=0.575，P=0.902＞0.05, there are no statistically significant differences between the twogroups.Conclusion: Compared to the other two groups，the curative effect ofpalmoplantar pustulosis treated with Acitretin and Tripterygium Glycosides isvery good，and side effect without increased significantly.