Changes And Clinical Significance Of TGF-β1and CTGF In Patients With Type2Diabetic Nephropathy

Objective：To investigate transforming growth factor-β1(TGF-β1) andconnective tissue growth factor (CTGF) level and clinical significance of type2diabetic nephropathy patients in different stages.Methods: To divide96type2diabetes patients (DM group) into threesubgroups according to ratio of urinary albumin/creatinine (ACR): normalACR (<30mg/g、A group), microalbunminuria group (30-300mg/g、Bgroup), macroalbunminuria group (>300mg/g、C group). To test the level ofserum TGF-β1、CTGF of30normal persons（D group）and98type2diabetespatients.Results：①the TGF-β1、CTGF level of A、B、C group were significanthigher than D group(P <0.001); The factors level between B and C group hasno statistically significant difference (P>0.05);The factors level of C groupwas higher than that of A and B group(P <0.05).②the relationship betweenTGF-β1、CTGF and ACR was positive in DM group(r=0.5338、0.49451, P<0.001).Conclusion：TGF-β1、CTGF may anticipate the onset and developmentof DN,and may be a protective factor of DN. Testing and early specificblocking may offer an new direction for the diagnosis and treatment of DN.