Study On The Relationship Between Cholinesterase In Blood And ApacheⅢScores, Evaluation Of Disease Severity And Prognosis Of The Patients In Emergency Intensive Care Unit

Objective:To explore the relationship between cholinesterase in blood and acute physiology and chronic health evaluation III(APACHEⅢ) scores,evalua-tion of disease severity and prognosis of patients admitted to Emergency Intensive Care Unit (EICU).Methods:The APACHE Ⅲ scores of the patients of EICU were assessed, and the CHE concentrations were determinded in98patients. Patients were divided into various meter segmented according to the APACHEⅢscores. Compare the difference of fatality rate of each scoring segment. By the boundary of APACHEⅢscores score60points, all patients were divided into two group. Compare these group’s mortality rate. According to their prognosis, all patients were divided into two groups:survival group and death group, and the relationship between APACHE Ⅲ scores and the CHE concentration,prognosis were analyzed. Analysis of the relationship bet-ween changes in serum CHE, APACHE Ⅲ scores and the condition pro-gnosis.Results:The APACHE Ⅲ scores were taken every30points as a scoring seg ment. The fatality rate of the every group have no difference (P>0.05).APACHE Ⅲ scores60is divided into the boundaries. APACHE Ⅲ s-core (>60points) group, mortality was significantly higher than to the APACHE Ⅲ scores (0to60points) group (P<0.05). Death group serum CHE concentration was significantly lower in the survival group (P<0.01), APACHE Ⅲ scores was significantly higher in the survival group (P <0.01). Serum concentration of CHE and APACHE Ⅲ scores negatively correlated (r=0.983, P=0.003). With the APACHE Ⅲ scores increased, the concentration of CHE became lower, while mortality rate were raised (P<0.01)Conclusion:Serum CHE concentration and APACHE Ⅲ scores of EICU patients were negatively related. The score of APACHE III scores of60points as a better division of the severity of illness in patients with the dividing line. Determination of serum concentration of CHE and APACHE Ⅲscores c-an be used as EICU in patients with disease severity and prognosis asses- sment of meaningful two indicators.