Study On The Relationship Between Serum Hydrogen Sulfide Concentration And APACHE Ⅲ Scores And The Prognosis Of The Patients In Emergency Intensive Care Unit

Objective To explore the relationship between the changes of serum hydrogen sulfide (H₂S) concentration and acute physiology and chronic health evaluation III(APACHE III, AP III) scores and prognosis of patients admitted to Emergency Intensive Care Unit (EICU).Methods Serum H₂S levels were measured in 72 cases and in 12 controls by spectrophotometry; The AP III scores of the patients were assessed and the relationship between serum H₂S concentration and AP III score and prognosis were analyzed.Results (1) The average serum H₂S concentration of the 72 cases was (45.6±17.2) μmol·L^-1. The concentration in the survival group was (41. 1 + 14.7) μmol·L^-1, and which was significantly lower than in the dead group (62.8 ± 15.5 ) μmol·L^-1, (P <0.001). The average AP III score was (43. 6 + 26. 0). The AP III score was (37. 7 + 22. 2), and which was significantly lower than in the dead group (65.0 ± 29.6), (P <0. 001). the higher of the AP III scores, the higher of the serum H₂S concentration and the mortality (x²= 18. 48, P <0.01). (2) The higher of the serum H₂S concentration level, the higher of mortality (x²= 24.48, P<0.01).Serum H₂S concentration was negatively correlated with diastolic blood pressure (r =-0.42, P<0.01) and mean arterial pressure (r = -0. 40, P =0.005). Serum H₂S concentration also had positive correlation with heart rate(r = 0.55, P<0.01) and serum glucose (r = 0.70, P<0.01).Conclusion Serum H₂S levels were positively correlated with AP III score. There is an important role of changes of serum H₂S concentrations on judging thecondition and prognosis of patients admitted to EICU.