The Relationship Between Dyslipidemia And The Incidence Of Intracerebral Hemorrhage

Subject：This study aims to clear the relationship between dyslipidemia and intracerebralhemorrhage, providing clinical work about controlling dyslipidemia with theoretical basis.Methods: The retrospective collection in neurological in-patients department of the firsthospital of jilin university from January2010to December2011, there were1060patientswith intracerebral hemorrhage, which was established as intracerebral hemorrhage group.Besides, collecting in cerebrovascular disease screening outpatient service from October2010to February2012,289patients without intracerebral hemorrhage, which as thematched group. The record of the patients were gender, age, the history of dyslipidemia,whether statins taken, history of hypertension, diabetes or heart disease, smoking history,drinking history, the location of intracerebral hemorrhage, triglycerides (TG), cholesterol(TC), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol(LDL-C), lipoprotein-a [Lp (a)]. The measurement of data used t test, count data used the x2inspection; Many factors used stepwise logistic regression analysis; Many compares usedvariance analysis; There was P <0.05as the statistical significance for inspection standards.Results:(1) There were1060patients with intracerebral hemorrhage, male patients in656cases(61.89%), history of hypertension in841cases (79.34%), history of diabetes in139cases (13.11%), history of heart disease in218cases (20.57%), smoking history in721patients (68.02%), drinking history in807cases (76.13%). The matched group in289patients, cerebral infarction in187cases (64.71%), TIA in19cases (6.57%), the arterialnarrowing in54cases (18.69%), dizziness in23cases (7.96%), headache in6patients(2.08%),199male patients (68.86%), history of hypertension in138cases (47.75%), historyof diabetes in70cases (24.22%), history of heart disease in39cases (13.49%), smokinghistory in151patients (52.25%), drinking history in118cases (40.83%).(2)The higher TGlevel, the higher the risk of hemorrhage happened, significant difference (b=0.449, OR=1.567,95%CI:1.167~2.105, P <0.01); The higher TC level, the higher the risk ofhemorrhage happened, but no significant difference (b=0.232, OR=1.262,95%CI:0.811~1.963, P>0.05); The lower HDL-C level, the higher the risk of hemorrhage happened,significant difference (b=3.677, OR=0.025,95%CI:0.005~0.120, P <0.05).（3）According with the different location of bleeding, we divided intracerebral hemorrhagegroup into4subgroups, the basal ganglia of hemorrhage in768cases (72.45%), lobes of hemorrhage in145cases (13.68%), subtentorial of hemorrhage in122cases (11.51%),ventricular hemorrhage in25patients (2.36%).The level of TG, TC, LDL-C among groupswere in statistical significance (P <0.05), lobes of hemorrhage was the lowest levels.(4) Thelevel of TC, HDL-C, LP(a) in intracerebral hemorrhage group were higher than the matchedgroup, the difference was statistically significant(P <0.05).Conclusion:（1）The higher TG and (or) the lower HDL-C increased risk ofintracerebral hemorrhage；there is no correlation between TC and intracerebral hemorrhage.(2) The level of bloodlipid varies from different location of intracerebral hemorrhage, the TG,TC, LDL-C level of lobes hemorrhage was minimum.