Efficacy Of Domestic Rosuvastatin And Domestic Atorvastatin In Patients With Hyperlipidemia

Objective:To compare the efficacy and safety of domestic rosuvastatin and domestic atorvastatin in patients with hyperlipidemia.Methods:123patients with hyperlipidemia were randomized into A group、 B group、 C group. Forty-four patients in A group was treated with domestic rosuvastatin5mg· dd1, Forty patients in B group was treated with domestic atorvastatin10mg· dd1, Thirty-nine patients in C group was treated with domestic atorvastatin10mg· d-1for12weeks, respectively. All patients took lipids test before the treatment and4weeks,8weeks and12weeks after the treatment, TC、 TG、 LDL-C、HDL-C、 apoA、 apoB、 LP(a、 non-HDL-C、 LDL-C/HDL-C、apoB/apoAI were observed. Levels of safety indices including FPG,CK,Liver function(ALT、 AST),Renal function(BUN、 Cr), Serum bilirubin(TBIL、DBIL、IBIL), Blood tests and routine urine were detected and observed before the treatment and4weeks,8weeks and12weeks after the treatment.Adverse drug reaction and Cardiovascular events were also observed.Results:After12weeks treatment, The TC、 TG、 LDL-C、 apoB、 non-HDL-C、 LDL-C/HDL-C、 apoB/apoAI level decreased significantly in all three groups(P<0.05); there is no significant change in HDL-C、 apoAI、 LP(a) level before and afer the treatment(P>0.05). Comparison among groups, The TC、 LDL-C、 apoB、 apoB/apoAI reduction in A group were statistically and significantly greater than in B group(P<0.0167), there was no statistic difference between A and B groups in TG、非HDL-C、 LDL-C/HDL-C reduction(P>0.0167); The TC LDL-C、 apoB、非HDL-C、 LDL-C/HDL-C、 apoB/apoAI reduction in C group were statistically and significantly greater than in B group(P<0.0167), there was no statistic difference between C and B groups in TG reduction(P>0.0167);there was no statistic difference between A and C groups in TC、 TG、 LDL-C、 apoB、 Non-HDL-C、 LDL-C/HDL-C、 apoB/apoAI reduction(P>0.0167). There was no statistic difference in Safety index;No adverse reaction and Cardiovascular events related to the study medication were observed.Conclusion:Domestic rosuvastatin5mg· d-1presented the better effect on decreasing the blood lipid level compared with domestic atorvastatin l0mg· d-1in patients with hyperlipidemia; the effect was similar between the domestic rosuvastatin5mg· d-1and domestic atorvastatin20mg· d-1; domestic rosuvastatin5mg· d-1also had a good safety profile, and it is worthy of recommendation to patients with hyperlipidemia.