The Characteristics’ Differences Of Targets Exist In CVD Therapy Of Western Drugs And Traditional Chinese Medicine

As complicated diseases, cardiovascular diseases (CVDs) are usually related with many biological processes, for example, inflammation, oxidative stress, lipid metabolism, ligands mobilization disorder and mutation process. In the treatment, drug compounds usually directly interfere and regulate disease network, perform a function of curing the CVDs. By depending on integral and synergetic theory of treatment, Traditional Chinese Medicine (TCM),which was received thousands of years clinic tests, has-been proved that it have desirable effects on therapy of CVDs in multi-targets and multi-levels mechanism. In consideration of the good treatment of western drugs and TCM on CVDs, the differences existing in the two sets of targets is assistant for further understanding of mechanism of pathology in CVDs and sheds lights on designing better proposals for curing CVDs. This article studies the characteristics of currently reported targets for curing CVDs including family distribution, cell location, transcriptional control function and tissue distribution and pathway relation, and studies the different features of targets in pathways related to cure CVDs. At last, Salvianolic acid B was selected as an example to be analyzed. Under the investigating, some of the key issues pointed out are:1. western drugs influence mainly targets located cell membrane, upstream of relative pathways, while TCM can interfere some basic cellular pathways and interact with the protein which are located in down-flow of the pathways; 2. TCM not only affect these pathways which are interfered by western drugs, by alse impact other pathways to treat CVDs in some biological processes related with CVDs. Salvianolic acid B primarily influences immune biological process (inflammation) to cure CVD.