Effect Of Noninvasive Positive Pressure Ventilation On The Severe Cases Of Hand Foot And Mouth Disease

Objective: Explore the efficacy of noninvasive positive pressure ventilation foradjuvant treatment of severe hand, foot and mouth diseaseMethod:65cases in our hospital with severe hand, foot and mouth disease (2,3)were in involved between January2011and December2011, while the observationgroup of30patients and the control group of35cases. The observation group addnasal continuous positive airway pressure (NCPAP) on the basis of the conventionaltreatment(milrinone, a wave of nylon, gamma globulin and so on),observed twogroups of blood gases, heart rate, blood pressure, blood glucose, white blood cells,duration of hospitalization, disease progression, invasive mechanical ventilation andso on.Results: PaO2of observation and control groups, respectively (83.6±19.4) mmHgand (71.7±17.5) mmHg, the two have significant differences (P <0.05); PaCO2ofobservation and control groups, respectively (33.4±11.5) mmHg and (36.3±12.8)mmHg, the two have significant differences (P <0.05); SaO2of observation andcontrol groups, respectively (94.5±15.4)%and (89.3±17.6)%, the two there isa significant difference, P <0.05;Heart rate of the observation and control groups,respectively (112.3±12.2) beats/min and (125.5±13.4) beats/min, the two havesignificant differences (P <0.05); Blood pressure the observation group (90.3±10.7)/(52.5±6.8) mm Hg, and the control group (108.2±9.9)/(64.3±5.5) between the twosignificant differences, P <0.05; WBC of the observation and control groups,respectively (9.3±2.3) x109.L-1and (9.2±3.6) x109.L-1, there was no significantdifference (P>0.05). Blood sugar observation and control groups, respectively(5.3±1.7) c/mmpl.L1and (5.5±1.2) c/mmpl.L1,there was no significant difference (P>0.05). Observation group and control group length of stay (9.2±2.1) days (13.2±4.6)days,the two have significant differences (P <0.05); Progression2of the observationgroup and control group: Zero case of observation progresses to stage3,7cases ofcontrol group progress to stage3, which has significant differences (P<0.05);Progression2of the observation group and control group: Zero case of observation progresses to stage4,8cases of control group progress to stage4, which hassignificant differences (P <0.05); The observation group and control group, incidenceof invasive mechanical ventilation are0%and20%respectively, having significantlydifference (P <0.05).Conclusions: Using NCPAP treatment for the severe hand, foot and mouth diseaseon the basis of the conventional treatment has an important role in improvinghypoxemia and circulatory function, shortening hospital stays,reducing invasivemechanical ventilation, preventing severe cases to critically ill patients.