148Cases Of Epithelial Oarian Cancer Prognosis Factors Analysis

Objective: Retrospective analysis of148patients with epithelial ovariancancer, to explore the influence of age, menstrual history of fertility,preoperative serum CA125, histological type and differentiation, surgical-pathologic stage, lymph node dissection, lymph node metastasis,chemotherapy and resistance gene namely MDR1, TOPOII, ERCC1, PTEN,Livin on the prognosis in epithelial ovarian cancer patients.Methods: Statistical analysis were performed using SPSS18.0software.Enumeration data were compared with χ2test.Using Kaplan-Meier method tocalculate survival analyses and depicts survival curve. The log-rank test wasused for univariate analysis, and the Cox regression model for multivariateanalysis. Statistical significance was considered for P<0.05.Results:1All the148cases,71(48%) cases were younger than55years,77(52%)cases were old than55years, univariate analysis showed there3-year survivalrates were76%and74.5%, the difference between the two sets of survivalcurves had no significant (P>0.05).2Univariate analysis showed that menarche age, menopause age,pregnancy, parity had no effect on the prognosis of epithelial ovarian cancerpatients (P>0.05); it's also found that different menopause age had effect onthe histological type (P <0.05), but had no effect on the histological grade andsurgical-pathologic stage (P>0.05).3In the study,there were57cases (38.5%) in serum CA125≤500U/mlgroup,30cases (20.3%) in500U/ml to1,000U/ml group and61cases(41.2%) in≥1000U/ml group, univariate analysis showed there3-yearsurvival rates were78.8%,76.1%and72%, the difference among the threesets of survival curves had no significant (P>0.05); in the study,we found theexpression levels of CA125had effect on the surgical-pathological stage (P <0.05), CA125expression higher in stage III and stage IV than in stage I andstage II.4In the study,13cases (8.8%) in stageⅠgroup,22cases (14.9%) instage II group,106cases (71.6%) in stage III group,7patients (4.7%) in stageIV group, Univariate analysis showed there3-year survival rates were100%,87.5%,70.7%,64.3%, the difference among the four sets of survival curveshad statistically significant (P <0.05).5In stage II, III and IV group,54cases (40%) of patients have beentreated by chemotherapy less than6times,and81cases (60%) have beentreated more than6times, univariate analysis showed there3-year survivalrates were60.9%,82.8%, the difference between the two sets of survivalcurves had statistically significant (P <0.05).6Univariate analysis showed that MDR1, TOPOII, ERCC1, PTEN andLivin were not effect on the the prognosis of epithelial ovarian cancer patients(P>0.05). But it's found that the positive expression rate of PTEN in thechemotherapy-sensitive group was significantly higher than in the resistantgroup (P <0.05).7Univariate analysis showed that: histological type, histologicaldifferentiation, lymph node metastasis, surgical removal of lymph nodes hadno effect on the prognosis (P>0.05).8Multivariate analysis showed that surgical-pathologic staging is anindependent risk factor to the prognosis of epithelial ovarian cancer patients (P<0.05).Conclusion:1Menarche age, menopause age, number of pregnancies, procreativetimes had no effect on the prognosis of epithelial ovarian cancer patients. Butwe also found that in the menopause age≥50years group, there are moreserous carcinoma than the <50years group.2The level of preoperative serum CA125had no effect on the prognosisof epithelial ovarian cancer patients, but there are differences expression inthe different surgical-pathological stage, it expression higher in stage III and IV than in I and II.3Surgical-pathological staging of epithelial ovarian cancer is aprognostic factors, and it also an independent prognostic factor. the3-yearsurvival rate of stage Ⅲ and stage IV patients is lower than stageⅠand stageⅡpatients, it's suggesting that to the epithelial ovarian cancer patients, thelater surgery-pathological stage, the worse prognosis.4The advanced epithelial ovarian cancer patients with chemotherapy <6times have worse prognosis than that have chemotherapy≥6times, it'ssuggesting that the standard chemotherapy can improve the survival rate ofpatients.5MDR1, TOPOII, ERCC1, PTEN, Livin are not affect the prognosis ofpatients with epithelial ovarian cancer. However, the study found that thepositive expression rate of PTEN in the chemotherapy-sensitive group wassignificantly higher than in the resistant group,it's suggesting that PTEN geneexpression reduce plays a role in the occurrence of drug resistance.6Patients'age, histological type, differentiation grade, lymph nodemetastasis, surgical removal of lymph nodes had no effect on the prognosis.