Clinical Effect Of Hormone Replacement Therapy Or Alendronate Sodium On Postemenopausal Osteoporosis

Objective:To compare the clinical effect and safty between hormone replacement therapy (HRT) and alendronate sodium treatment on postmenopausal osteoporosis.Method:62 patients were divided into two groups by two different treatments. Among them,30 patients were treated with regimen of HRT and 32 patients were treated with alendronate sodium for one year. The clinical effect was evaluated by the changes of bone density and side effects of these two drugs. One year before and after treatment, we examined BMD of the lumbar vertebrae (L1-L4) and left femoral neck with dual energy x-ray, serum estradiol (E2) and follicle-stimulating hormone (FSH) with macroparticle chemiluminescence immunoassay instrument, and thinkness of uterine endometrium or breast masses with B-ultrasound.Results:One year after treatment with HRT or alendronate sodium, BMD of the lumbar vertebrae (L1-L4) was increased around 4.19% or 4.43%, repectively. Meanwhile, BMD of the left femoral neck was also increased around 3.01% and 2.45%. E2 level was increased around 33.57 pg/ml and FSH level was decreased around 32.39 mU/ml after treatment with HRT. In contrast, E2 level was decreased around 1.96 pg/ml and FSH level was increased around 5.22 mU/ml after admistration of alendronate sodium. The thinkness of uterine endometrium was increased around 5.36% or decreased around 7.62% after treatment with HRT or alendronate sodium, repectively. No breast masses were found in both groups.Conclusion:Both HRT and alendronate sodium treatment can significantly improved the BMD of lumbar vertebrae (L1-L4) and left femoral neck in women who suffered from postmenopausal osteoporosis. Meanwhile, HRT increased E2 level and decreased FSH level which is an ideal situation after treatment. Also, the side effect to the uterine and mammary gland was relatively less under the treatment of HRT.