The Expression And Clinical Significance Of CREB In Acute Myeloid Leukemia And Myelodysplastic Syndromes

Objective To study the expression and clinical significance of CREB mRNA in acute myeloid leukemia and myelodysplastic syndromesMethods Real-time quantitative PCR was performed to detect CREB mRNA expression in peripheral blood from 12 cases of acute myeloid leukemia (AML), 13 cases of myelodysplastic syndrome (MDS), as well as 9 cases of Non-hematologic malignancies as the controls.Results the expression levels of CREB among the three groups were statistically different(p<0.05);The expression levels of CREB mRNA in AML patients were 4.390±1.840,those in MDS patients were 1.423±0.425,Both the AML and MDS groups exhibited signifcantly higher CREB expression levels than control group (P= 0.00 and P= 0.01,respectively), the expression levels of CREB mRNA among the three groups showed an increasing trend.Conclusions CREB can act as a complementary indicator to judge condition and identify myelodysplastic syndrome and acute myeloid leukemia. The mechanism of CREB exhibited higher expression in AML and MDS is required further study.