Homoharringtonine And Low-Dose Cytosine Arabinoside Combined With G-CSF Or GM-CSF Administered In Patients With Advanced Myelodysplastic Syndromes, Relapsed Or Refractory Acute Myeloid Leukemia(AML) And Geriatric AML

Objectives: To evaluate the effectiveness and toxicity of a combination chemotherapy of homoharringtonine, low-dose cytarabine and G-CSF or GM-CSF(HAG regimen) in treating patients with advanced MDS, relapsed or refractory AML and geriatric AML, and to investigate the prognostic factors for response of the treatments. Methods: 42 patients with advanced MDS or poor-prognosis AML who received HAG chemotherapy for remission induction between January 2002 and July 2005 were followed up till April 2006. Clinical and laboratory data of all these patients concerned with a)general information such as age, gender, physical status, clinical manifestations, blood routine and bone marrow tests, serum biochemical analysis, etc; b)medical interventions including induction chemotherapy, post-remission treatment, and management of complications, etc; c)conditions of remission, relapse-free survival and overall survival after HAG induction therapy; d)adverse events following HAG induction therapy,...