Pharmacodynamic Study Of Qianlie Suppository

Purpose:To study the Qianlie suppository on the effect of chronic prostatitis and the basis of drug action.Method: Within the prostate to the normal rats injected with 25% Xiaozhiling injection induced chronic non-bacterial prostatitis model;Within the prostate to the normal rats injected with E. coli(E. coli 1.5×108 / ml) and cooled to 45℃0.2% agar 1:1 of 0.2ml mixture induced model of chronic bacterial prostatitis; 1% carrageenan induced rat paw edema;Left ear before and after applying both sides of 0.02ml xylene induced ear swelling;0.6% acetic acid induced mice writhing;In vitro antibacterial test.Results: Qianlie suppository on the non-bacterial prostatitis role model, Qianlie suppository on the coefficient significantly inhibited prostate, Compared with model group in the Qianlie suppositories of high, Medium and low dose groups were significantly different(P<0.01或P<0.001);Qianlie suppositories on chronic non-bacterial prostatitis rats in each group significantly inhibited white blood cell count(P<0.05或P<0.01);Observed under light microscope Qianlie suppositories in prostate lesions,Invasion of inflammatory cells and fiber significantly inhibited cell proliferation,Improve the environment with the role of prostate tissue lesions.(2)Qianlie suppositories on the model of chronic bacterial prostatitis effects, High-dose group of Qianlie suppository bacterial prostatitis rat model of prostate index were significantly inhibited(P<0.05);Qianlie suppository can inhibit the effectiveness of white blood cell count,Compared with model group,Qianlie suppository high ,medium dose group are significant differences(P<0.05或P<0.01); Qianlie suppository on the Histopathology of rat prostate,As can be seen from the biopsy,Qianlie suppository high,medium dose group to hyperplasia fiber and lesions of prostate inhibited the extent of the role and improve,Significant improvement in the pathological,Compared with the control group no significant difference.(3)Qianlie suppository on carrageenan induced rat paw edema,Qianlie suppository high, medium dose group of the carrageenin rat paw edema caused by varying degrees of inhibition,Compared with the control group,There was a significant difference(P<0.05或P<0.01),The anti-inflammatory role in inflammation after 1~5h most obvious,And dose-dependent manner;Qianlie suppository on the xylene ear edema of mice,Qianlie suppository of high, medium and low dose group of the ear swelling induced by xylene in mice and significantly inhibited the swelling rate,Compared with the control group there was significant difference,And dose-dependent manner(.4)Qianlie suppository of research shows that analgesic effects,Qianlie suppository in mice induced by acetic acid significantly inhibited writhing,Qianlie suppositories of high,medium and low dose groups inhibition rates were 25.5%,12.7%,10.0%.(5)Qianlie suppository on the selected Staphylococcus aureus , Escherichia coli , Streptococcus pneumoniae , alpha hemolytic streptococcus, beta-hemolytic streptococcus,Pseudomonas aeruginosa,Proteus have different degrees of inhibition.Conclusion: Qianlie suppositoryt on chronic prostatitis treatment significantly.