Changes Of Seng In The Serum And Umbilical Artery Flow In Pre-Eclampsia

Objective:To observe the serum levels of soluble Endoglin (sEng) and umbilical artery blood RI, S/D ratio changes in preeclampsia and normal pregnant control group.To explore the role of sEng in the pathogenesis of preeclampsia and the values of sEng and umbilical artery blood flow detection in the clinical application.Method:1.Enzyme linked immunosorbent assay was employed to detect sEng levels in serum of 30 women with preeclampsia (study group,of which mild preeclampsia 16 cases,severe preeclampsia 14 cases) and 30 normal pregnant women (control group).2.Color doppler flow imaging was used to detect umbilical artery flow RI,S/D ratio changes of 30 women with preeclampsia (study group) and 30 normal pregnant women (control group). 3.To discuss the correlation between sEng and umbilical artery blood flow.Result:1.Compared with control group, The level of sEng in serum of the preeclampsia group (3.97±1.00) ng/ml was singnificantly higher than that of the control group (2.82±0.45) ng/ml, P<0.01;The level of sEng in serum of the severe preeclampsia group (4.87+0.47) ng/ml was singnificantly higher than that of the mild preeclampsia group (3.18±0.57) ng/ml, (P <0.05)2. S/D and RI values of preeclampsia group were 3.13±0.43 and 0.68±0.04; S/D and RI values of control group were 2.31±0.12 and 0.56±0.03; Compared with the control group, preeclampsia umbilical artery blood flow S/D and RI were significantly higher than normal pregnancy control group, (P<0.05). S/D and RI values of mild preeclampsia group were 2.83±0.14 and 0.65±0.02; S/D and RI values of severe preeclampsia grpup were 3.49±0.38 and 0.71±0.03. Compared with each other, severe preeclampsia grpup umbilical artery blood flow S/D and RI were significantly higher than mild preeclampsia grpup, (P<0.05)Conclusion: 1.There was singnificantly positive correlation between the level of sEng in serum and umbilical artery flow RI,S/D ratio changes of preeclampsia group.2. The serum level of sEng of the preeclampsia group was positively correlated with the severity of the desease.3. Fetal umbilical artery blood flow can predict the severity of preeclampsia and surveillance the status of the fetus in utero.4. sEng may influence the uterine spiral arteries in the vascular remodeling involved in the pathogenesis of preeclampsia.