Clinical Study Of TOU BIAO QIN QI Therapy In The Treatment Of Exogenous Febrile Upper Respiratory Tract Infection

Objective:To investigate the clinical efficacy and the safety of antipyretic granule (TOU BIAO QIN QI therapy) in treating the patients with viral upper respiratory tract infection.Methods:A total of 60 patients with viral upper respiratory tract infection recruited from Jangsu Provincial Hospital (from September to December in 2010) were randomly divided into three groups (1:1:1 ratio) in a double-blind fashion. The treatment group (treated with febrifuge granule,20 cases), the control group (treated with bufferin cold,20 cases) and the low dose febrifuge granule control group were 20 cases. The course of treatment was 3 days in these groups. The changes of body temperature and the clinical symptoms were observed and analyzed before and after treatment including①Antipyretic effect (the range of the reduction of patients' temperature were measured 1,2,3,4 hours after medication),②Fever clearance times (the time from the start of antipyretic therapy to the time that the temperature fell below and remained less or equal 37.2℃),③linical relevance (effectiveness of relief of clinical symptoms).④Clinical cure rate.Result:(1) Antipyretic effects:Fever subsided markedly in the treatment group (treated with febrifuge granule)within 4 hours after medication (P<0.05), and the placebo control group showed no reduction of temperature within 4 hours (P>0.05). The bufferin cold control group had fever subsided within 4 hours (P<0.05), but there were no significant statistical difference between the treatment group and control group (P>0.05). There were significant difference between the placebo control group and the febrifuge granule group and bufferin cold control group within 4 hours (P<0.05).Of these patients in the treatment group, the incidence of patients with fever reduction (≥0.5℃) within 4 hours after initial medication was around 66.7%, the bufferin cold control group was 68.4%, and the placebo control group was 40%.It indicated that both the febrifuge granule group and the bufferin cold control group had significant antipyretic effect without difference, and the placebo group had no therapeutic effect.(2) Fever clearance time:Of these patients in the febrifuge granule group, the incidence of patients with fever subsided (<37.2℃) within 72 hours after medication was around 94.5%, and the average fever clearance time was 20.81 hours. The incidence of bufferin cold control group was better than the placebo control group (P<0.05), There was no significant difference between the febrifuge granule group and the bufferin cold control group (P>0.05).According to statistical results; there was significant effect in the combination therapy with placebo group. However, febrifuge granule group did not find the effect in combined therapy, which indicated that the efficacy of the febrifuge granule group was better than the placebo group. (3) Clinical relevance:The total effective rate of treatment group (febrifuge granule group) was more than 90%, which was significantly higher than bufferin cold control group and the placebo control group on decreasing body temperature, ameliorating clinical symptoms such as mild fever,high fever,shivering,chills,sweating,nasal stiffness,rhinorrhea,sneezing,sore throat,poor appetite,nausea,vomiting,diarrhea,and constipation etc. The effective rate of cough cure was around 54%, which was better than bufferin cold control group and the placebo control group.(4) Clinical cure rate:The effective rate of febrifuge granule group was around 67%, which was significantly higher than those of bufferin cold control group(32%) and the placebo control group(30%)(P<0.05)。Conclusion:Antipyretic granule (TOU BIAO QIN QI therapy) could be used as an effective method in the treatment of viral upper respiratory tract infection fever.