Expression Of CD44s And Integrinβ1 In Human Glioma And Their Clinical Significance

ObjectiveGliomas are the most common malignant tumors in the central nervous system,account for about 35.26%-60.69%.The biological characteristics of glioma are infiltrating growth and easy relapse, the prognosis is poor.The alteration to adhesion capability of cell adhesion molecule(CAMs) are the key factors to tumor development, invasion and metastasis.As primary members of CAMs, CD44 and the integrin family play important roles in a serial events that occur during invasion, metastasis, prognosis of tumor and tumor angiogenesis.The aim of this study was to study the clinicopathologic significance of CD44s and Integrin(31 protein expression in human glioma.We also discussed the relevance of CD44s and Integrinβ1 in the human brain glioma pathogenesis.Methods60 gliomas specimens(from 2009 to 2010) were obtained from the first aff iliated hospital of Zhengzhou university,10 cases of normal brain tissue samp les taken from traumatic brain injuries and Cerebral hemorrhage patients.There were 4 gradeⅠ,26 gradeⅡ,19 gradeⅢand 11 gradeⅤgliomas, accordin g to the WHO classification.We detect the levels CD44s and Integrinβ1 of 60 glioma cases and 10 cases of normal brain tissue samples through immunohis tochemical methodResultsThe positive rate of CD44s expression in glioma specimen was 86.67%,in 10 cases of normal tissues were 10.00%, high grade group was 96.67% and higher obviously than that in low grade group(P<0.05). The positive rate of Integrinβ1 expression in 10 cases of normal tissues were 0.00%, in 60 cases of brain glioma were 68.33%. in high grade group was 90.00% and higher obviously than that in low grade group (P<0.05). There was a positive relationship between expression of Integrinβ1 and CD44s(P<0.01).ConclusionCD44s and Integrinβ1 are closely related with pathologic grade, proliferation of glioma.The role of CD44s and Integrinβ1 in adhesion process interactions and are not independent of each other factors, They affect each other in the occurrence and development of gliomas.