Investigation On The Relative Association Of CD44s And Fibronectin Expression With Endometriosis

Objective To study on the expression of CD44s and fibronectin in endometriosis. Method Expression of CD44s and fibronectin were evaluated by immunohistochemistry method in entopic from 22 patients and in ectopic from 45 patients with endometriosis and the endometrial tissues of 20 non-endometriosis . Results CD44s is restricted to epithelial cells ; fibronectin is restricted to stroma,their expression remained constants thoughout the menstrual cycle.Decreased expressin of CD44s and fibronectin in epithelial and stroma in endometriosis was found in eutopic endometrium (P<0.05) and ectopic endometrium (P<0.05) as compared with endometrium in controls. CD44s expression was significantly higher in CD44s and fibronectin secretory than in proliferative phase endometrium in eutopic endometrium and endometrium in controls;we also observed a decreased expression of CD44s and fibronectin in advanced stages of the disease. Conclusions In patients with endometriosis CD44s and fibronectin expression changed significantly from eutopic to ectopic endodisease attribute which maybe related to the development of endometriosis and infertility.and...