Survival Analysis And 107 Cases Of Clinicopathologic Characteristics In Breast Cancer Patients Aged Of ≤35 Between Uyghur And Han Ethnic Group.

Objective:To investigate the clinicopathologic characteristics and factors of survival in breast cancer patients aged of<35 between Uyghur and Han ethnic group. Methods:A total of 107 young patients(aged 35 years old or less) were evaluated, with operative patients, their comfirmed pathologic proof and complete clinical data, according to the admission notes of 137 patients in the XinJiang Tumor Hospital from 2004 to 2007, which are divided into two groups:Uyghur(51) and Han(56).Compare the nationality, age composition, the time from symptom recognition to medical consultation, tumor size, TNM stage, histologic type, status of axillary lymph nodes metastasis, biological indicator, molecular subtype, the way of therapy and factors of survival between the Uyghur group and the Han group were retrospectively analyzed. Statistical analysis was performed in SPSS version 17.0. Results were compared, using the pearson chi-square, fisher's exact test and rank-sum test, Kaplan-Meier Survival(log-rank test used in comparison of two groups), multivariate analysis(cox regression model),5%or lower p-value is considered to be statistically significant.Results:In the two groups:more patients age30 years old or greater,tumor size 2-5cm,â…¡â…¢stage, invasive non-specific cancer, Luminal A type accounting for the majority, Luminal B type taking the second one,there are no statistically significant differences in ER,PR,HER-2,Ki-67 between two groups.The time from symptom recognition to medical consultation and status of axillary lymph nodes metastasis in Uyghur group are significantly highter than those in the Han group.3 year disease-free survival rates for the Uyghur is lower as compared to their Han counterparts. Univariate analysis indicates nationality, status of axillary lymph nodes metastasis, TNM stage, the way of therapy are the factors of survival, multivariate analysis indicates nationality and TNM stage are the independent factors of survival. Conclusions:This study reveales nationality and TNM stage are maybe the independent factors of survival.