The Feature Of Breast Cancer In Young Women (<40Years Old)

Objective:To explore the feature of breast cancer in young women (<40years old) by comparing the overall survival time and clinicopathological features between the young breast cancer patients (<40years old) and the elder breast cancer patients (older than40years old).Methods:From June1996to April2011,1393breast cancer patients who received treatment in Sir Run Run Shaw Hospital were retrospectively analyzed, including194patients younger than40years old,1184patients older than40years old and8patients with unknown age. Chi square test is used to identify the clinicopathological features. Kaplan-Meier survival analysis is used to identify the overall survival time.Result:No significant difference in overall survival time between young group (<40years old) and elder group (≥40years old) breast cancer (P=0.485>0.05).The molecular subtype differs between young group and elder group with statistically significance (P=0.046≤0.05), which shows more Her-2overexpression in Luminal subtype of the young group than that of the elder group. However, the percentage of ER、PR、Her-2shows no significant difference between two groups (P>0.05). The lymph node stage is later in young group than the elder group, without significant difference in Tumor stage, metastasis stage and TNM stage between two groups (P>0.05). The percentage of breast conserving therapy in Young group is higher than the elder with statistically significance (P=0.011<0.05) rather than modified radical mastoidectomy.Conclusion:1. Young breast cancer (<40years old) has more poor prognostic factors than the elder(≥40years old), such as later lymph node stage and more Her-2overexpression in Luminal subtype.2. Young breast cancer (<40years old) patients prefer breast conserving therapy than modified radical mastoidectomy, comparing with the elder(≥40years old).3. Young breast cancer (<40years old) doesn’t mean longer or shorter overall survival time.