Barrett 's Esophagus In Patients With Esophageal Mucosa Substance P And Vasoactive Intestinal Peptide Expression

Objective Though the record of bile acid and the inflammation of Helibacteria Pylori(HP), analyze the expression of substance P and VIP, primarily study the pathogenesis, the role of the bile acid reflux and HP in the development of Barrett's esophagus.Methods 58 patients with Barrett's esophagus and 25 control subjects (undergone negative endoscopy) selected randomly, the expression of substance P and VIP in biopsy specimens from the esophageal mucosa by immunohistochemistry.Results 1.The expression of substance P in patients with Barrett's esophagus compared with that of control subjects: reduced significantly (P<0.05); the expression of VIP increased significantly (P<0.05);2. The expression of substance P in LSBE compared with that of SSBE: reduced significantly (P<0.05); the expression of VIP increased significantly (P<0.05); the rate of intestinal metaplasia in LSBE was higher than that in SSBE(P<0.05); 3.The expression of substance P and VIP in different shape BE had not differences (P>0.05); 4. The expression of substance P in gastric metaplasia(+) BE was higher than that in intestinal metaplasia(+) BE, the expression of VIP lower than that in intestinal metaplasia(+) BE, there were both significant differences (P<0.05); 5.The expression of substance P in bile reflux BE was lower than that in non bile reflux BE (P< 0.05), the expression of VIP lower than that in non bile reflux BE (P<0.05); 6.The positive rate of HP in BE was lower than the control(P<0.05),that between intestinal metaplasia BE and gastric metaplasia BE had not different (P>0.05) 7.The rate of intestinal metaplasia in bile acid BE was higher than that in non bile reflux BE, there was significant differences (P<0.05).Conclusion 1. The dyssecretosis of substance P and VIP exist in Barrett's esophagus,and it had influence on LESP; 2.Function of LESP in LSBE has more serious disorder than SSBE; that in intestinal metaplasia(+) BE more serious than in gastric metaplasia(+) BE;3.The bile acid reflux had role in intestinal metaplasia of BE.