Non-motor Symptoms Of Patients With Essential Tremor

Partâ… Olfactory function in patients with Essential TremorObjective: To study the olfactory function in patients with Essential Tremor(ET), as well as the relationship with patients'age, disease duration, onset age and disease severity.Methods: T&T olfacmeter (Takasuna Co., Ltd, Tokyo, Japan) tested the olfaction of 62 ET patients, 50 PD patients and 60 healthy adults. We compared olfactory function in three groups in the view of olfaction detection and olfaction recognition, as well as distribution of different olfaction in these groups. We used Fahn-Tolosa-Marin Tremor Rating Scale(TRS) to assess tremor severity and functional disability in 62 patients with ET. We determined whether olfaction of ET patients had correlation with patients'age, disease duration, onset age and disease severity.Results: In 62 patients with ET, 32 (51.6%) had olfactory dysfunction, 10 patients(16.1%) olfaction loss partly, 22 patients(35.5%) had hyposmia; In PD group, 44 patients(88%) had olfactory dysfunction, with 5 patients(10%) anosmia, 16 patients(32%) olfactory loss partly, 23 patients(46%) hyposmia; In control, 18 adults(30%) had hyposmia, 42 adults(70%) euosmia. In ET group, there were not significantly differences in age, gender, education, disease duration, past cigarettes smoker, onset age, severity of disease between those with and without olfactory deficit. There was not significant association observed between the olfactory function and the onset age, disease duration, TRS scores but age.Conclusions: The olfactory function was found decreased in ET patients, hyposmia occupied most in patients with olfaction deficit, but not as severe as in PD patients. Age was related to olfactory deficit in ET.Partâ…¡Clinical study on non-motor symptoms of Essential Tremor Objective: To survey the prevalence, distribution of non-motor symptoms (NMS) in essential tremor(ET) and the relationship with age, gender, disease duration and whether to be treated.Methods: The Parkinson's disease non-motor symptoms questionnaire (NMS Quest) and mini-mental state examination (MMSE) were used to explore non-motor symptoms in ET patients and control. Fahn-Tolosa-Marin Tremor Rating Scale (TRS) was used to assess motor symptoms and influences in ET patients'ordinary life.Results: In ET group, a range of NMS occurred across all disease stages. Every patient had 5 different non-motor symptoms on average. Compared with control, The prevalence of 7 non-motor symptoms were more common, including decline of remembering, intense vivid dreams, anhedonia, depression, anxiety, sleep disorders, olfactory or gustatory dysfunction. The incidences of decline of remembering, intense vivid dreams, anxiety were 58.1%, 48.4%, 33.9%, respectively,ranked top 3 in ET patients. There was not significant correlation between NMS score and TRS score, gender, disease duration and weather to be treated.Conclusions: Besides kinetic tremor or positional tremor, NMS may occur in ET patients, including decline of remembering, anxiety, sleep disorders, sensory disability and so on, which need to be recognized and treated in time.