Particle Treatment Of Chronic Urticaria In Qidan Interest-sensitive Experimental And Clinical Research

Objective:1. To detect the anti-hypersensitivity effect of Qidan rest sensitivity particle based on animal model. To research the mechanism of anti-hypersensitivity prelimarily. 2. Through clinical observation of Qidan rest sensitivity particle to study the therapy of chronic urticaria.Methods:To research the typeâ…£hypersensitivity induced by DNFB, at the same time study the swollen ears of small rats. Give the small rats tail vein injection of 0.0125% low molecular weight dextran solution, observed the number of pruritus within 30 minutes after injection.To detect the diameters of blue plaque on type I allergic SD rats model. Thirty patients with chronic urticaria were chosen by certain standards and given Qidan rest sensitivity particle oral treatment. Use the designs of self-contrast before and after treatment. Taken one month as a period of treatment. The clinical symptoms and the changes of the lesions were observed in the test. And the effects were evaluated later.Results:The results of animal experiments:That large and middle dose group of Qidan rest sensitivity particle can inhibit by 24 hours after apparent delayed skin hypersensitivity caused by DNFB, and decrease the swollen ears of small rats. (p<0. 01). That large dose group of Qidan rest sensitivity panicle can significantly reduce the number of dextran-induced pruritus, which means its can stop itching effectively. (p<0. 01). That large and middle dose group of Qidan rest sensitivity particle can inhibit the blue plaque of SD rats back significantly(p<0. 05), which means Qidan rest sensitivity particle can inhibit the typeâ… hypersensitivity. The results of clinical observation:In effect rate,clinical symptoms and the lesions changes, were significantly improved after treatment.Conclusion:Animal experiments proved that Qidan rest sensitivity particle can inhibit the typeâ… andâ…£hypersensitivity .Clinical observation proved that under the guidance of "treating disease before" theory, Qidan rest sensitivity particle are traditional Chinese medicine that can changes skin sensitivity to normal, from the results,to improve the efficiency of chronic urticaria precise, it' s worth of getting a further research.