Benefit Lung And Kidney Of Delay Mechanism Of Action Of Aging

ObjectiveSet up the model of subacut aging rats, Respectivel give "BuYiFeiShen" prescription drugs,vitamin E and the normal diet, Detection the change of serume SOD, serume MDA, brain lipofuscin and T-lymphocyte subsets after administration, Then interpretation the Mechanism of "BuYiFeiShen" therapy anti-aging. Based on the experimental results, clearde the Relations of "BuYiFeiShen" Method and aging, as well as the role and effectiveness of "BuYiFeiShen" Method in anti-aging. At the same time, Discussion the pathogenesis of aging in tradtional Chinese medicine and explore new ways for improve the quality of life of older persons and anti-aging.MethodsForty 3-month-old Kunming Clean Wister male rats, weighing 220±20 grams, were randomly divided into four groups. Respectively as normal group, model group, "BuYiFeiShen" group and vitamin E group. Make. Aging model with the model group, "BuYiFeiShen" group vitamin E group through neck back subcutaneous injection of D-galactose ,and give "BuYiFeiShen" therapy to "BuYiFeiShen" group, give vitamin E to vitamin E group, vitamin E. After respectively Administration six weeks, take the Materials and Detection the indicators serume SOD, serume MDA ,brain lipofuscin and T-lymphocyte subsets.ResultsModel group serum SOD activity significantly lower than the normal group, had the remarkable difference (P<0.01). Model group and "BuYiFeiShen" group had the remarkable difference (P<0.01), vitamin E group and"BuYiFeiShen"group had the remarkable difference (P<0.01).Model serum MDA is higher than other groups. Compared with normal group had a remarkable difference. Model group and "BuYiFeiShen" group had the remarkable difference (P<0.01), then,vitamin E group and"BuYiFeiShen"group had the difference (P<0.05). Model group brain lipofuscin higher than other groups. Compared with normal group had a remarkable difference. Model group and "BuYiFeiShen" group had the remarkable difference (P<0.01), then,vitamin E group and model group had the difference (P<0.05). Model group and "BuYiFeiShen" group had the remarkable difference (P<0.01). Compared with normal group"BuYiFeiShen" group had difference (P<0.05). Model group CD4,CD8 express rate and the ratio of CD4/CD8 are lower than those of other groups, Compared with normal group had a remarkable difference. Model group and "BuYiFeiShen" group had the remarkable difference (P<0.01) For CD4,CD8 express rate vitamin E group and model group had the remarkable difference (P<0.01). For the ratio of CD4/CD8 vitamin E group and model group had the difference (P<0.05)Conclusion:The experimental results showed that "BuYiFi Shen " Method can significantly improval serum SOD activity and reduce the content of serum MDA of aging model, lower the level of lipid peroxidation, anti-aging. At the same time "BuYiFi Shen " Therapy also proved effectively in inhibiting rats brain lipofuscin Produce and gather, protect the normal cell. The results also showed that replenishing Feishen of aging rats can increase blood CD4,CD8 expression rate and CD4/CD8 ratio, improve the immune status.