| Objective: In traditional Chinese medicine,activating and harmonizing Qi-blood therapy are thought to be important in delaying aging process. To clarify this mechanism, Chaihuguizhi decoction was selected to exploring the anti-aging effects on the aging rats induced by D-galactose.Methods: 52Wistar rats were randomly divided into normal group,model group, Chaihuguizhi decoction treatment group and vitamin EC treatment group (VEC group) (13 in each group). Chaihuguizhi decoction was daily administrated by oral (0.9ml/kg). The same volume of physiological salt solution and vie EC (7mg/100g) were administrated in the same way for model and VEC group respectively. The superoxide dismutase (SOD) activity was detected with the Xanthine oxidase method. The monoamine oxidase (MAO) activity and serum hemolysin was detected with the colorimetry method.Results: In comparing with the model group, the SOD activity of serum and hippocampus were significantly increased (P＜0.05), but the MAO activity was significantly decreased (P＜0.05) in Chaihuguizhi treatment group. In addition, the serum hemolysin level were also significantly higher in Chaihuguizhi treatment group than that of the model group (P＜0.05).Conclusion: Chaihuguizhi decoction was proved to have anti-aging effects on the aging rats induced by D-galactose. This may be caused by its effect on increasing the ability of anti-oxidizing and strengthening the immunity function. In addition, this study also provided some mechanistic evidence for the activating and harmonizing Qi-blood therapy. |
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