Based On Hepatocyte Growth Factor Receptor C-met, Anti-cancer Lead Compounds

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a multifunctional cell factor which predominantly expressed in mesenchymal origin. C-Met tyrosine kinase is the only known high-affinity receptor for HGF. C-Met and HGF are dysregulated in human cancers and are also believed to contribute to the development, progression and metastasis of cancers . Preliminary studies show inhibiting the HGF/C-Met cell signal path will retrieve the growth, invasion and metastasis of tumor cells. HGF/MET have be represented a world-wide recognized target for cancer therapy.According to the biological characteristics of HGF/C-Met, we devised a platform to screen new drugs for cancer. Screened about 2000 compounds, we find one Compound named W014, which belong to derivate of indolin-2-one. W014 could inhibit the activation of HGF/C-Met cell signal path and PI3K cell signal path in the low nanomolar range. Although W014 can inhibitor the growth of many kinds of tumor cell, it brings more conspicuous result to HepG2. The results show W014 can be a lead compound for cancer therapy, and lay the foundation of new medicine.