Mild Cognitive Impairment Syndromes And Cognitive Characteristics

Objective: Investigating the syndromes defined by traditional Chinese medicine(TCM) and the cognitive characteristics in mild cognitive impairment (MCI) in order to supply informations for early diagnosis and intervention of dementia .Methods:Using case control to compare aMCI,AD and NCS.Cognitive functions were assessed using various kinds of neuropsychology scales:Mini-Mental State Examination (MMSE),delayed story memery of Wechsler Memory Scale(WMS) ,Clinical dementia rate scale(CDR),clock drawing test(CDT), Hamilton depress rate scale(HAMD),Hachinski Inchemic Scale Hachinski(HIS).Meanwhile a syndrome scale was used to diagnose the syndromes of subjects.Results:1. The average of age of the aMCI group was higher than the NCS group(P<0.05).There was significantly difference(P<0.01) on educational level and no difference(P>0.05)on birth season among the three groups. There was significantly difference on SBP(P<0.01),difference on DBP(P<0.05) and significantly difference on BMI(P<0.01)between the aMCI group and the NCS group .2. The deficiency of kidney-essence,the deficiency of QI-blood and phlegm muddy were important syndromes of aMCI and AD groups.Than the aMCI group,the AD group had significantly higher frequencies of syndromes of phlegm muddy and deficiency of QI-blood (P<0.01),as well as higher frequencies of syndromes of dominance of heat in the interior(P<0.05).There were dependability between these items as follow:the score of CDT ,the score of special orientation force and Deficiency of kidney Qi(P<0.05);the score of MMSE, the ability of speech and peformance, instantly memery and deficiency of QI-blood (P<0.05);time oriental force and dominance of heat in the interior, deficiency of QI-blood(P<0.05);the force of attention and calculation and syndromes of phlegm muddy(P<0.05).3.The scores of time orientation and time-delayed memery of the aMCI group were significantly higher than the AD group(P<0.01), The scores of the force of attention and calculation and the ability of speech and peformance of the aMCI group were significantly lower than the NCS group(P<0.01).Ignoring educational level and age,the subjects could be taken as MCI when the score of MMSE was about 25.Suggestions: The educational level,the difference of pulse pressure,BMI are the risk factors of the aMCI group.With the cognitive impairment aggravating ,the syndrome of asthenia in origin and asthenia in superficiality was more obviously. There were dependability between various kinds of syndrome and cognition.MMSE had some help to screen the aMCI group.