Experimental Study Of The The Disinfection Suppository In The Treatment Of Cervical Inflammation

Cervicitis, especially Cervical Human Papillomatous Virus (HPV)infection is one of gynecic genital disease, lt is clearly relationshipbetween HPV and cervicitis, cervical intraepithelial neoplasia (CIN)even cervical carcinoma. It has been ascertained that high risk humanpapillomatous virus (HPV) infection is the main factors in cervicalcarcinoma and lesion precaneer. When it comes to the treatmentcervicitis, there are some curative effects of physical treatment oroperation, which always by means of destroying and ruining. However,these treatments often bring a large of damage for organism, at the sametime, they have more or less complications. And now there are still nospecific remedy to give consideration to both HPV infection and cervicalerosion. Therefore, it is necessity on clinic and has a significance foracademic circles to develop Chinese medicine to give consideration tothe two or more things.QingDu Suppository has been studied by Prof. Jin Zhe for many yearsas well as gained well curative effect. On the base of about severalyears' research, it is clear that QingDuShuan can not only block HPVreplication, but also treat cervical erosion well. The finishedexperiments show that QingDu Suppository can effectively stimulate themice's spleen cell to produce INF and has little ill effect or toxicityon animals.On the bases of these studies mentioned above, many experimentswere done to investigate the pharmacologic action of QingDu Suppositoryonwards. It includ having determining IL-1, IL-6, Ih-8, and TNF-αlevels in serum of Cervicitis rats model which were set up byadministering phenol mucilage into vagina, having vaginal occult bloodtest(OBT) of Cervicitis rats model, and observing the histopathologicalchange on cervix uteri tissue of cervicitis rats. The experiments showthat QingDu Suppository have not obviously analgesic effect, but it canadjust inflammatory reaction related cytokine of Cervicitis rats modeland can effectively lessen the OBT of Cervicitis rats model,whichsignificant improved clinical symptom of cervicitis. In addition,Qingdu suppository also can lessen the inflammatory reaction onpathology.