Capsule And Copper Nanoparticles. Force Pharmacodynamics And Mechanism Of Anti-osteoporosis

Nanometer copper is a primary ingredient in the traditional formula ligu capsules,which mainly used in the treatment of osteoporosis. In this paper,multiple kinds of animal models were used to evaluate the drug's anti-osteoporotic effects, immunologic effects and toxicity. We also used a new research method-Serum pharmacology to study the mechanism of nanometer copper in preventing and treating osteoporosis.In GC-induced OP, the results showed that nanometer copper and ligu capsule obviously increased the BMD and bending strength of femur. The drugs also improved the bone weight, the dry bone weight, the ash weight, the volume, the length and the diameter of the femur. The levels of Ca, P, Mg in serum in nanometer copper and ligu capsules groups were significantly higher than those in model group. While the levels of serum ALP and HOP/Cre were decreased. The data indicated that nanometer copper and ligu capsules could prevent and treat osteoporosis in model rats induced by dexamethasone.Nanometer copper and ligu capsules could apparently improve the BMD in OVX rats and increased the femur volume and the length. Compared with the model group, the serum CT was increased while the serum BGP was decreased in copper and ligu groups. The drugs didnot influence the level of serum E₂.In the treating test, nanometer copper and ligu capsules obviously increased the BMD and the weights, the dry weights, the ash weights, the volumes and the lengthes of femurs. The drugs improved the kidney index and the level of Ca, P, Mg in serum. At the same time, the level of HOP in serum was lowered.In RA-induced OP, nanometer copper and ligu capsule obviously increased...