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OBJECT:Study the pharmacokinetics of minocycline for injection in healthy human volunteers. In order to provide reasonable clinical administration regimen and accurate scientific evidence, then obtain effective, safe and reasonable application on clinic.METHODS:Twelve healthy volunteers were selected to receive a single dose of minocycline 100,200 and 300mg within 2 hours infusion in an open randomized threefold cross-over study. There was a week intermission in every project. Blood samples were taken for detecting serum concentration before dosing and at 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12, 24,48 and 72 h after completion of the intravenous infusion.The concentrations of minocycline in serum were determined by a high pressure liquid chromatography (HPLC) method.Results:1. The method of HPLC is simple, sensitive and accurate .It is suitable...