Folium Anti Drug Active Substances Based Research

Folium Isatidis is the most commonly-used traditional Chinese medicine, bitter in flavor, cold in property, posses heat-clearing and detoxicating, cooling blood and removing ecchymoses effects, used for febricity diseases such as fever, dipsosis, hematemesis, aurigo, etc. Chinese Pharmacopoeia edition 2005 record the source of Folium Isatidis, which is from the dried leaves of Folium Isatidis. because different areas have different medical custom, the records about Folium Isatidis in bencaology, pharmacognosy, phytotaxonomy is different and confused, even one has several names. It is not only bring about big barriers to the standard process in crude drug and preparation, but also the further study in quality control, chemical constituent, pharmacodynamic action. In order to provide history basis to the research of the Folium Isatidis crude drug, we looked up the ancients" literature and explain the origination and historical development of Folium Isatidis.Endotoxin is definited as LPS components of cell wall, which is released while Gram's negative bacteria grows or dies. When it invades into blood stream of body and acts with host cell, it causes a series of pathophysiological process and endotoxin diseases such as fever, shock, DIC, MODS and so on. Traditional Chinese medicine always diagnosis the early symptom of endotoxin disease as "sthenic fever", and "toxic heat" and "pathogen" is regard as the reason for the disease.Folium Isatidis is one of the most commonly-used traditional Chinese medicine for heat-clearing and detoxicating purpose. It is reported that Folium Isatidis also has anti-endotoxic activity. Under the support of the National Science Foundation, the paper aimed at revealing the antiendotoxin active substance agreeing with the antipyretic in folium Isatidis. It also targets on providing the basis for developing newer and more effective antiendotoxic medicines.We evaluate the antiendotoxic activity of the preceding five fractions combining pharmacological experiments in vitro and in vivo. The rate of degradation of...