| l.Subject of Analysis: The use of gongliuxiao Granule in treating myoma of uterusof blood stasis due to Qi stugnancy .2.Aims of Analysis,Design of Analysis,Observation Methods,Tanget Group andStandard of Diagnosis:(l)Aims of Analysis:To observe the clinical effect and safety of Gongliuxiao Granule which was used to treat myoma of uterus of blood stasis due to Qi stugnancy,and supply scientific evidence for the clinical usage of Gongliuxiao Granule. (2)Design of Analysis:72 cases of patients of myoma of uterus of blood stasis due to Qi stugnancy which had been diagnosed in our outpatient department were shosed and divided randomly into high dose treatment group,low dose treatment group and control group(Guizhifuling Capsule). high dose treatment group contains 20 cases,low dose treatment group contains 20 cases, control group contains 20 cases. It was a random , double-blind , double - mock research.Observe the change of size of myoma of uterus,the change of the blood stasis due to Qi stugnancy symptoms,and the changes of themenstrual cycle,amount clour and quality.Compare the clinical effect and safety. (3)Observation Methods:The main of observation methods is the size of myoma of uterus.And selecting 4 secondary symptoms to obverse thecases.For exammple the masses of blow the navel,pain in the area blow the navel,distending in the blow the navel,diatending of the breast, themenstrual cycle,amount clour and quality.As for somatoscopy estrogen regular blood and urine,liver(ALT),the function of the kidneys(Cr,BUN)and ECG etc were taken into observe safety of the medicine. (4)Tanget Group:Woman aged between 18-45. (5)Standard of Diagnosis:Women who were diagnosed by westen doctors as and myoma of uterus by Chinese doctors as blood stasis due to Qi stugnancy.3.Treatment and Observation MethodsBefore one month,patient stop the use of drinking and treatment which was used to treat myoma of uterus.They were respectively given Gongliuxiao Granule and Guizhifulinf capsule.twenty weeks as a course. 4.Methords of Statistical AnalysisX ± SD average value for statistical analysis .Analysis F was used to compare in several.Analysis X was used in count data.Analysis R was used in grade data.Withed the result of the checked amount of analysis and the relative pvalue,using double test.P > 0.05 is ineffective, P < 0.05 is effective, P < 0.01 is very effective. 5.The effectiveness of The Prescription(1) Standard on evaluating in myoma of uterus Recovery:disappearance of myoma of uterus Very effective:contract 1/2 of myoma of uterus Effectivexontract 1/3 of myoma of uterus Ineffective:not lessened of myoma of uterus (2)The effectiveness of The Treatment by Chinese Doctors Recovery:% in improvement in clinical symption ≥ 90% Very effective: % in improvement in clinical symption 70% < 90% Effective: % in improvement in clinical symption 30% < 70% Ineffective: % in improvement in clinical symption < 30% 6.result(l)The effectiveness of myoma of uterus of blood stasis due to Qi stugnancy: In Gongliuxiao Granule high dose treatment group,the cured rate is 13.04%,markedly effective rate is 34.78%,effective rate is 4.35%,and the total effective rate is 86.96%. In Gongliuxiao Granule low dose treatment group,the cured rate is 22.73%,markedly effective rate is 22.73%,effective rate is 9.09%.and the total effective rate is 76.19%. In Guizhifuling Capsule control group,the cured rate is 8.07%,markedly effective rate is 34.78%,effective rate is 13.04%,and the total effective rate is 90.91%. There is no significant difference of pre-treatment and pos-treatment in the three groups.Three groups cannot contract myoma of uterus.(2)The clinical curative effect myoma of uterus of blood stasis due to Qistugnancy: In Gongliuxiao Granule high dose treatment group,the cured rate is 4.35%,markedly effective rate is 21.74%,effective rate is 65.22%,and the total effective rate is 95.65%. In Gongliuxiao Granule low dose treatment group,the cured rate is 13.64%,markedly effective rate is 18.18%,effective rate is 59.09%.and the total effective rate is 86.3... |
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