Syndecan-1 In Colorectal Cancer And Syndecan-1, Tenascin Expression And Clinical Significance Of Survivin Expression In Colorectal Carcinoma And Its Clinical Significance

Objective: To evaluate changes in syndecan-1 expression during thedevelopment of human colorectal cancer. Correlation between tumourexpression of syndecan-1 and clinicopathological characteristics of patientswith colorectal carcinoma was studied. Methods: 58 human colorectal cancer patients, 12 of colorectaladenoma and 9 normal colorectal epithelium were studied, the expressionof syndecan-1 in them were examined by immunohistochemical method. Results: Histologically normal mucosa shows strong membranousand cytoplasmic staining of syndecan-1, while the poorly differentiatedadenocarcinoma shows a significant reduction in the expression ofsyndecan-1 than that of well and moderately differentiatedadenocarcinoma(P=0.003<0.05, P=0.001<0.05). Clinically, the incidenceof metastasis to distant place in patients with syndecan-1-negative tumors 4重庆医科大学硕士学位论文was significantly high (t=2.23, P=0.03<0.05). When analyzed forprognostic significance, patients with syndecan-1-positive cancer showed abetter prognosis than those with syndecan-1-negative cancer(P=0.0046<0.05), and a multivariate Cox proportional hazard modelidentified reduced syndecan-1 expression as an independent predictivefactor for overall survival (P=0.001). Conclusion: These results suggest that the reduction ofsyndecan-1 expression in colorectal cancer cell is closely related to theinvasive character of colorectal cancer. The evaluation ofsyndecan-1 expression in colorectal cancer may allow prediction ofpatients' survival after surgery.