Liver Depression Premenstrual Syndrome, Clinical Observations And Experimental Results

As the change of social-psychological-medical pattern, more and more researches into the premenstrual syndrome (PMS), the incidence of which is comparatively high and which greatly affects women's life and work, are carried out. This article bases itself on Traditional Chinese Medicine (TCM) theories of women's physiological characteristics and the liver physiological and pathological change, combines the gynecology's plural-factors hypotheses of PMS, and explores that "Jin Qin Capsules "that have the function to course the liver and rectify the qi and harmonize the blood can improve the mental and physiological syndromes of "the state of liver depression PMS" and interfere with sexual hormone. At the same time, this paper emphasizes the comparative analysis of the experimental research results of the liver depressed and hyperestrogenic model sex rats, explores the important factors of PMS-the ration between estrin and progestogen is imbalance and the estrin is higher, the pathological and physiological similarities and differences of the liver depression syndrome of gynecology of TCM and the similarities and differences of the interference response of "Jin Qin Capsules "to the pathological and physiological processes; as well as conducts preliminary analysis of the similarities and differences of the change of centric 5-HT (5-hydroxy tryptamine) and 5-HT2A receptor under the two states in order to enrich the gynecology of TCM theories of "the blood is the base of life" and "the liver is the congenital base of life". The comparative analysis of the experimental results indicates that "the state of liver depression" sex rats' E2, P, B -EP is rising, which is like the state of hyperestrogenism, however, after the interference of the TCM which can course the liver and rectify the qi and harmonize the blood, both of the two model sex rats' E2, P, B -EP have fallen. The TCM can also affect the content and the activity of the centric nerve-transmitter and its receptor and improve the mental and physiological syndromes of "the state of liver depression PMS".