The Gloomy Qingwei Law And Phlegm And Collaterals Fat Diet Induced Insulin Resistance Rat Model Of Insulin Sensitivity To Improve The Role Of Research

In recent decade, the research on Insulin Resistance (IR) has being a hot subject in medical field. Through long term study of epidemiology of large sample, it has been proved IR is the pathophysiological basis and risky factor of many metabolic disturbances of endocrine, such as obesity, hyperinsulinaemia, lipidemia or metabolic disturbances of lipoprotein, impaired glucose tolerance, hypertension, type 2 diabetes mellitus and cardiovascular disease in common, and it has closed relationship with onset of illness. This paper reviews a large number of literature including clinical and experimental studies of TCM on IR in recent years. It is shown that some syndrome-types of TCM, such as stagnation of Phlegm and Blood type, Hyperactivity of Liver-Yang type, deficiency of both Qi and Yin type, deficiency of both Yin and Yang Type are closely related with IR.Based on his long clinical experience, Professor Tong Xiaolin presents stagnant heat of Liver and Stomach is major expression of Insulin Resistance Syndrome (IRS) in it's earlier period, hence in this period, the therapy of dispersing hepatic stagnation and removing gastric heat is key link to prevent and treat IRS. In this subject, we successfully copied model rats of IR by high fat diet. According to above-mentioned views, the model rats were randomly divided into five groups: normal group, matched control group , Rosiglitazone group, Kai Yu Qing Wei group, and Hua Tan Tong Luo group. Clamp tests and insulin tolerance tests were taken, in addition body weights and content of abdominal fat, serum glucose, insulin concentrations, triglyceride in liver and muscle, t-PA and PAI, and free fatty acid were determined. By analysing the change of above marker after treatment, we try to compare the effects of two kinds of therapy (method of dispersing hepatic stagnation and removing gastric heat; method of eliminating phlegm and removing meridian obstruction) on releasing IR and increasing Insulin Sensitivity of model rats.The prescription of Kai Yu Qing Wei granule bases on Bupleuri decoction which comes from written by Zhang Zhongjing. It is composed of Chinese Thorowax Root, Skullcap, Coptidis, Root of Herbaceous Peony, Pinellia,Aurantii Immaturi, Rhubarb, and it has the function of dispersing hepatic stagnation and eliminating heat by purgation. The prescription of Hua Tan Tong Luo decoction also comes from . It consists of Pinellia, Coptidis, Mongolian Snakegourd, Leech, Peach Kernel, and it has efficacy of eliminating phlegm by cooling heat and to promoting blood circulation to remove meridian obstruction.Result: Both of two kinds of therapy can significantly reduce body weights and content of abdominal fat, the level of triglyceride in liver, the level of PAI; and increase the level of t-PA. But from the results of clamp tests and insulin tolerance tests, Kai Yu Qing Wei group has more marked effect than Hua Tan Tong Luo group on improving the insulin sensitivity of model rats. It seem to show that stagnant heat of Liver and Stomach is major expression of IRS in early stage, the therapy of dispersing hepatic stagnation and removing gastric heat plays important role in this period.