Lipid Metabolism Of Phlegm And Removing Blood Stasis Method Comparison Experiment

Objective: Blood lipids including mainly piasma cholesterol and triglyceride have been proved to correlate closely with atherosclerosis. Improving blood lipids metabolism and accelerating its elimination is favorable to get rid of the atcerosclerosis. Traditional Chinese medical has original ways to prevent and cure hyper lipoproteinemia. Since the mmuddy phlegm and torpid blood stasis take an important effect on the hyper lipoproteinemia occurrence and developing, it's an important method to reduce phlegm , remove blood stasis and promote circulation for remedy hyper lipoproteinemia. In order to probe in the two ways' function and status during the course of treatment, the experiment plans to make use of modern medical science and biological research methods, then proceeds the comparative research and analysis between two ways. It attempts to compare the curative effect and function mechanism of the traditional Chinese medicine compound prescription during the treatment course. Then through the experiment it maybe verify the connotation of adjust fat function and provide scientific basis for the clinical application.Methods: 1 , The theory research adopts the way to read and clean out the relative medical documents with clinical experience. 2, The rats were drivided into six groups randomly: normal group, model group, simvastatin group, Wendan Decoction group, Taohongsiwu Decoction group, fired mixture group. The model was made by the method of feeding high grease feeds. Choose forty eight male mice to the ordinary feeding a week, no medicine group with ordinary feeds. The rest five groups with high grease foods, then after six weeks change to the ordinary feeding method but with 0.9% sodium chloride injection, simvastatin suspend liquid, Wendan Decoctionfried liquid, Taohongsiwu Decoctionfried liquid and traditional Chinese medicine mixture fried liquid for filling stomach curative, then examine the lipid content of twenty-four hour stool after sixty nine days. Meantime proceed histopathology observation to the aorta and liver organization for the model group. Examine the serum lipids and carbon monoxide content and other index.Results: 1, Muddy phlegm and blood stasis are the major illness reasons for hyper lipoproteinemia. Removing phlegm and eliminating stasis is the important method to treat hyper lipoproteinemia. 2, Both Wendan Decoction group and Taohongsiwu Decoction group could obviously improve the index variation. Taohongsiwu Decoction was more remarkable than Wendan Decoction, the fried mixture has a more superior effect but less than simvastatin group in several index. All curative groups had some treatment changes comparative with the normal group medicine and the model group (P<0.05 or P<0.01). The Taohongsiwu Decoction group treatment was not so obvious than Wendan Decoction group. Both of them were more effective than the fired mixture group. Simvastatin group is almost equal to the Chinese medicine. All traditional Chinese medicine groups could obviously reduce blood serum triglyceride, cholesterol and increase carbon monoxide content. The difference were remarkable(P<0.05 or P<0.01). Taohongsiwu Decoction group was more remarkable than Wendan Decoction group, (P<0.05 or P<0.01).The fired mixture group was more remarkable than Taohongsiwu Decoction group and Wendan Decoction group(P<0.05 or P<0.01). All experiment groups had a less effect and notable difference to high...